A comparative study of the effect of local infiltration of hydrocortisone dose preemptively on pain and nausea and vomiting after laparoscopic cholecystectomy surgery

Articles in Press

Document Type : Original Article(s)

Authors

1 Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associated Professor, of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran

3 Isfahan University of medical science, Isfahan, Iran

10.48305/jims.2025.45227.2462

Abstract

This triple-blind clinical trial study was conducted in 1400 and 1401 on the patients of Isfahan Al-Zahra Hospital of Isfahan who underwent laparoscopic cholecystectomy due to cholecystitis. Sampling was done by random allocation method. The studied patients were divided into groups: A, 100mg of hydrocortisone; group B, 50mg of hydrocortisone; and group C, 20cc of normal saline without medication. Pain intensity and nausea intensity was measured by VAS numerical scale in recovery and up to 24 hours after the operation.
Result: In this study, the pain intensity in the 100mg hydrocortisone group was significantly lower than the 50mg hydrocortisone group and lower than the control group (P = 0.003). Also, the average amount of painkillers, in the control group was significantly more than the 50mg hydrocortisone group and more than the 100mg hydrocortisone group (P<0.001).
And the average time of the first need for painkillers in the control group was significantly less than the 50mg hydrocortisone group and less than the 100mg hydrocortisone group (P<0.001). The severity of nausea (P=0.40), the frequency of vomiting (P=0.06) and the number of anti-emetic doses received (P=0.06) and the average time of the first need for anti-emetic(p=0.09) were not significantly different between the three groups in recovery and 24 hours after surgery.
Conclusion: local infiltration of two doses of hydrocortisone pre-emptively after laparoscopic cholecystectomy had favorable effects on pain and had no effect on postoperative nausea and vomiting.

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Journal of Isfahan Medical School

Articles in Press, Accepted Manuscript
Available Online from 06 October 2025

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History

  • Receive Date: 14 May 2025
  • Accept Date: 19 July 2025

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