مروری بر نقش میکروبیوم دستگاه تناسلی زنان در سلامت باروری

نوع مقاله : مقاله مروری

نویسندگان

1 دکتری میکروبیولوژی، گروه میکروبیولوژی، دانشگاه آزاد اسلامی، واحد فلاورجان، اصفهان، ایران

2 استادیار، گروه زنان و زایمان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 دانشیار، گروه میکروبیولوژی، دانشگاه آزاد اسلامی، واحد فلاورجان، اصفهان، ایران

10.48305/jims.v43.i828.1027

چکیده

مقاله مروری




مقدمه: سلامت باروری زنان، با چالش‌های بنیادینی روبه‌روست. پژوهش‌های اخیر حاکی از آن است که میکروبیوم با آناتومی، بافت‌شناسی و سیستم ایمنی دستگاه تناسلی زنان، که ارکان اصلی حفظ سلامت باروری و پیشگیری از عوارض نامطلوب بارداری به شمار می‌روند، در تعامل است. با این حال، سازوکارهای دقیقی که زیربنای این تعامل و تأثیر میکروبیوم بر عملکردهای فیزیولوژیکی دستگاه تناسلی هستند، هنوز ناشناخته باقی مانده‌اند و به‌عنوان حوزه‌ای نوین در پژوهش‌های میکرواکولوژی دستگاه تناسلی زنان مطرح می‌شوند.
روش‌ها: در این مقاله مروری، با نگاهی نوین، به بررسی سازوکارهای تعامل میان میکروبیوم و آناتومی، بافت‌شناسی، و سیستم ایمنی دستگاه تناسلی زنان پرداخته شده است. همچنین عواملی که بر ترکیب میکروبیوم این دستگاه تأثیر می‌گذارند و رویکردهای پزشکی در مدیریت سلامت دستگاه تناسلی زنان مبتنی بر میکروبیوم مورد تحلیل قرار گرفته‌اند.
یافته‌ها: این مطالعه بر نقش محوری میکروبیوم دستگاه تناسلی زنان در حفظ سلامت باروری و تأثیر آن بر بروز بیماری‌های مرتبط تأکید می‌کند. یافته‌های این پژوهش از اکتشاف رویکردهای نوآورانه در پیشگیری، پایش و درمان بیماری‌های دستگاه تناسلی زنان بر پایه‌ی میکروبیوم حمایت می‌کند.
نتیجه‌گیری: این بررسی، گامی مهم در جهت درک عمیق‌تر ارتباط پیچیده‌ی میکروبیوم با سلامت باروری زنان است و افق‌های تازه‌ای را برای پژوهش‌های آینده و توسعه‌ی راهبردهای درمانی هدفمند می‌گشاید.

تازه های تحقیق

عاطفه بیات: Google Scholar

فاطمه صفری: Google Scholar

هتاو قاسمی تهرانی: Google Scholar, PubMed 

منیر دودی:  Google Scholar, PubMed 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

A Review of the Role of the Female Reproductive Tract Microbiome in Reproductive Health

نویسندگان [English]

  • Atefeh Bayat 1
  • Fatemeh Safari 1
  • Hatav Ghasemi Tehrani 2
  • Monir Doudi 3
1 PhD in Microbiology, Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2 Assistant Professor, Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
چکیده [English]

Background: Women's reproductive health faces fundamental challenges. Recent studies indicate that the microbiome interacts with the anatomy, histology, and immune system of the female reproductive tract, key elements in maintaining reproductive health and preventing adverse pregnancy outcomes. However, the precise mechanisms underlying this interaction and the microbiome's influence on the physiological functions of the reproductive tract remain unknown, emerging as a novel field in female reproductive tract microecology research.
Methods: This review article employs a novel approach to examine the interaction mechanisms between the microbiome and the anatomy, histology, and immune system of the female reproductive tract. It also analyzes factors affecting the composition of this microbiome and microbiome-based medical approaches in managing female reproductive health.
Findings: The study highlights the pivotal role of the female reproductive tract microbiome in maintaining reproductive health and its impact on the development of related disorders. The findings support the exploration of innovative microbiome-based approaches for the prevention, monitoring, and treatment of female reproductive tract diseases.
Conclusion: This review represents a significant step toward a deeper understanding of the complex relationship between the microbiome and women's reproductive health, while opening new horizons for future research and the development of targeted therapeutic strategies.

کلیدواژه‌ها [English]

  • Women's Reproductive Health
  • Microbiome
  • Female Genital Tract
  • Genital Anatomy
  • Microecology

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مجله دانشکده پزشکی اصفهان
دوره 43، شماره 828
هفته 4، مهر
مهر و آبان 1404
صفحه 1027-1043

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  • تاریخ دریافت: 18 اسفند 1403
  • تاریخ پذیرش: 12 آبان 1404

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