A Review of the Role of the Female Reproductive Tract Microbiome in Reproductive Health

Document Type : Review Article

Authors

1 PhD in Microbiology, Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

2 Assistant Professor, Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran

3 Associate Professor, Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

10.48305/jims.v43.i828.1027

Abstract

Background: Women's reproductive health faces fundamental challenges. Recent studies indicate that the microbiome interacts with the anatomy, histology, and immune system of the female reproductive tract, key elements in maintaining reproductive health and preventing adverse pregnancy outcomes. However, the precise mechanisms underlying this interaction and the microbiome's influence on the physiological functions of the reproductive tract remain unknown, emerging as a novel field in female reproductive tract microecology research.
Methods: This review article employs a novel approach to examine the interaction mechanisms between the microbiome and the anatomy, histology, and immune system of the female reproductive tract. It also analyzes factors affecting the composition of this microbiome and microbiome-based medical approaches in managing female reproductive health.
Findings: The study highlights the pivotal role of the female reproductive tract microbiome in maintaining reproductive health and its impact on the development of related disorders. The findings support the exploration of innovative microbiome-based approaches for the prevention, monitoring, and treatment of female reproductive tract diseases.
Conclusion: This review represents a significant step toward a deeper understanding of the complex relationship between the microbiome and women's reproductive health, while opening new horizons for future research and the development of targeted therapeutic strategies.

Highlights

Atefeh Bayat: Google Scholar

Fatemeh Safari: Google Scholar

Hatav Ghasemi Tehrani:  Google Scholar, PubMed 

Monir Doudi:  Google Scholar, PubMed 

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 43, Issue 828
4th Week, October
September and October 2025
Pages 1027-1043

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  • Receive Date: 08 March 2025
  • Accept Date: 03 November 2025

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