Frequency distribution of risk factors in various types of soft tissue sarcomas

Document Type : Original Article(s)

Authors

1 Professor, Department of Pathology, School of Medicine, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

10.48305/jims.v43.i831.1133

Abstract

Background: Soft tissue sarcomas (STSs) are rare neoplasms that account for approximately 1 to 2 % of all adult malignancies. In this regard, this study aimed to assess the frequency distribution of risk factors in various types of STSs.
Methods: This analytical descriptive study was conducted on medical reports of patients with definitive diagnosis of STSs in Department of pathology of Alzahra hospital. Data including age, gender, previous history of radiation, previous history of receiving high-dose radiation during treatment cancer, recurrence of disease, history of first-degree family members, exposure to chemicals components, primary location, and type of STSs were extracted from medical reports and interview. Chi square test was used for analysis of data.
Findings: Among 100 patients, 46 patients were men and 54 patients were women. The most frequency of STSs in men and women was myxoid liposarcoma and leiomyosarcoma with frequency 9 and 8, respectively. The most frequency of STSs and primary locations was liposarcoma (n = 16) and retroperitoneum (n = 24). High grade of STSs was seen in 64 % of patients. No significant difference was seen among STSs in terms, gender, history of radiation, genetic disease, immunodeficiency disease, exposure to chemicals components, and trauma (P > 0.05). Significant difference was seen among the types of STSs in terms of age, primary location, grade and recurrence of disease (P < 0.05).
Conclusion: According to these finding, the most frequency of STSs types was liposarcoma. In addition, the types of STSs were influenced by age, and involved primary location. Moreover, the types of STSs may affect grade and recurrence of disease. However, it seems that the types of STSs were not dependent to gender, history of radiation, genetic disease, immunodeficiency disease, exposure to chemicals components and trauma.

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References

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Journal of Isfahan Medical School
Volume 43, Issue 831
3rd Week November
November and December 2025
Pages 1133-1139

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History

  • Receive Date: 26 April 2025
  • Accept Date: 30 August 2025

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