23-Year-Old Girl with Prolonged Cholestasis Caused by Hepatitis A Virus Infection; A Case Report

Document Type : Case Report

Authors

1 MD, Medical Student, Students Research Committee, School of Medicine, AND Social Determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran

2 Professor of Infectious Disease, School of Medicine, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran

10.48305/jims.v43.i838.1497

Abstract

Background: Hepatitis is the most common acute viral hepatitis worldwide, and it is often a benign disease, but it is rare in cases with uncommon clinical forms such as recurrent hepatitis, long-term hepatitis, and hepatitis cholestasis. The type of cholestasis is characterized by itching, jaundice, increased serum bilirubin and alkaline phosphatase.
Case Report: A 23-year-old female patient with no history of any specific disease complained of severe itching with fever, chills, nausea, vomiting, brown urine and dark yellowish skin discoloration; The patient's itching was generalized without petechiae and purpura, which was referred to an infectious specialist with the initial diagnosis of jaundice. According to the results obtained from the history and paraclinic, the infectious specialist diagnoses hepatitis A disease for the patient and prescribes a ten-day treatment period with the drugs Ursodeoxycholic acid and Prednisolone along with complete rest and adherence to the diet (not consuming red food and spices) starts.
Findings: The maximum level of total bilirubin was 9mg/dl during three months of the disease period, after that, the bilirubin levels gradually started to decrease and after about 2 months, the levels reached the normal level. A similar trend was observed for SGOT and SGPT.
Conclusion: This study shows that despite the rarity of cholestasis caused by hepatitis, cholestasis should be considered in patients with hepatitis A, and hepatitis A should also be considered among the differential diagnoses of cholestatic jaundice patients.

Keywords

Main Subjects


  1. Koff RS. Hepatitis A. Lancet 1998; 351(9116): 1643-9.
  2. Kushwaha V, Agrawal P, Shukla V. Hepatitis A virus infection induced prolonged cholestasis: a case report. Journal of Clinical Research and Applied Medicine 2022; 2(1): 15-8.
  3. Coppola N, Genovese D, Pisaturo M, Taffon S, Argentini C, Pasquale G, et al. Acute hepatitis with severe cholestasis and prolonged clinical course due to hepatitis A virus Ia and Ib coinfection. Clin Infect Dis 2007; 44(9): e73-e7.
  4. Nokhodian Z, Ataei B, Babak A, Yaran M, Pahlevani A. Seroprevalence of Hepatitis A among street children, Isfahan, Iran [in Persian]. J Isfahan Med Sch 2012; 30(178): 159-65.
  5. Purcell R, Emerson SU. Natural history and experimental models. In: Viral Hepatitis. 3rd ed. Oxford Blackwell Publishing; 2005. p. 109-25.
  6. Mondello P, Patti S, Pecoraro G, Portelli V, Cascio G, Spano C. Diphasic or prolonged course of viral hepatitis A in children. Boll Ist Sieroter Milan 1985; 64(6): 443-6.