Study Serum Level of Zinc In Benign Prostatic Hyperplasia and Prostatic Cancer Patients

Document Type : Original Article(s)

Authors

1 Infectious Diseases and Tropical Medicine Research Center, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

10.48305/jims.v43.i818.0642

Abstract

Background: Hypothesized that zinc level may be a more specific marker due to its high concentration in the prostate peripheral zone. In this regard, a study was conducted to evaluate the serum zinc level in patients with benign prostatic hyperplasia and prostate cancer at Ordibehesht, Noor, and Ali Asghar medical centers in Isfahan.
Methods: In this analytical cross-sectional study which was conducted in three independent health centers in Esfahan, 185 patients were randomly enrolled in the study after meeting inclusion criteria. The participants underwent 12 prostatic biopsies and blood samples were taken in order to assess the serum level of zinc. Then the patients were divided into three groups of BPH, prostatic cancer and a healthy age-matched individuals as control group. One-way ANOVA was used for data analysis.
Findings: The mean serum zinc level in the control group (85.43 ± 12.04 µg/dL) was significantly higher than in the BPH group (80.29 ± 11.10 µg/dL) and the prostate cancer group (76.61 ± 11.31 µg/dL) (P = 0.04). In contrast, the mean PSA level in the control group (2.65 ± 0.6 ng/mL) was significantly lower than in the BPH group (5.71 ± 8.02 ng/mL) and the prostate cancer group (10.73 ± 6.64 ng/mL) (P = 0.002).
Conclusion: The results of the study showed that serum Zn level was significantly lower in patients with prostatic cancer. The findings of this study can be used for health system professionals.

Highlights

Azar Baradaran: Google Scholar 

Mohammad Yazdani: Google Scholar 

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Journal of Isfahan Medical School
Volume 43, Issue 818
2nd Week, August
July and August 2025
Pages 642-647

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History

  • Receive Date: 22 April 2025
  • Accept Date: 13 September 2025

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