The Effect of Exercise Training on Adiponectin in Type 2 Diabetic Patients Based on Gender: A Systematic Review and Meta-Analysis

Document Type : Review Article

Authors

1 PhD. Candidate, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran

2 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, Iran

3 PhD Student, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran

4 MSc, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran

Abstract

Background: The purpose of this systematic review and meta-analysis is to examine the effect of exercise training on adiponectin levels in patients with type 2 diabetes mellitus (T2DM) based on gender.
Methods: This systematic review and meta-analysis were conducted based on the PRISMA guidelines and the Sex and Gender Equity in Research (SAGER). To extract relevant information for the study, reputable databases including PubMed, Web of Science, Scopus, Google Scholar, and the Persian language database (SID) were searched by two independent researchers to find studies that had examined the effect of exercise on adiponectin levels in individuals with T2DM. The combined effects of interventions were assessed as standardized mean differences (SMD) using a random-effects model. Sensitivity analysis was performed to evaluate the influence of specific studies on the overall results.
Findings: According to the findings of this meta-analysis, exercise training had a significant effect on adiponectin levels in women with T2DM (SMD = -0.77, 95% CI: (-0.35 to -1.18), P < 0.01), but no significant effect was observed in the analysis of data related to men with T2DM (SMD = -0.35, 95% CI: -0.06 to -0.77, P = 0.09).
Conclusion: Based on the results of this meta-analysis, exercise training can effectively play a role by controlling plasma levels of adiponectin as a non-pharmacological strategy in improving the complications caused by the disease in women with T2DM.

Highlights

Aref Mehdipour: Google Scholar

Seyed Morteza Tayeby: Google Scholar 

Ehsan Amiri: Google Scholar 

Keywords

References

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Journal of Isfahan Medical School
Volume 43, Issue 826
2nd Week, October
September and October 2025
Pages 956-968

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History

  • Receive Date: 19 May 2024
  • Accept Date: 11 June 2025

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