Mesenchymal Stem/Stromal Cell Therapy in Rheumatoid Arthritis: A Review of Clinical Trials

Document Type : Review Article

Authors

1 Assistant Professor, Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

2 MSc, Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

3 Professor, Department of Immunology, Pharmacological Research Center of Medical Plants, Mashhad University of Medical Sciences, Mashhad, Iran

10.48305/jims.v43.i822.0804

Abstract

Background: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovial hyperplasia and the production of autoantibodies that target joint tissues, cartilage, and other bodily structures, ultimately leading to the destruction of bone and cartilage. Conventional therapies for RA only relieve pain and inflammation but do not repair damaged tissue. Furthermore, side effects and drug resistance associated with these conventional treatments have been reported in some RA patients. Consequently, the poor prognosis of the disease and the lack of a definitive cure have prompted researchers to explore alternative treatment options. Mesenchymal stem cells (MSCs) represent one such promising therapeutic approach.
Methods: The therapeutic effects of MSCs have been evaluated in various research phases, including numerous clinical trials. This review aims to examine and present the immunological effects of MSC-based treatment for RA, based on studies published in the Web of Science and PubMed databases over the past 15 years.
Findings: The results of various studies indicate that MSCs can effectively reduce inflammation and alleviate pain in patients with RA by modulating immune system responses.
Conclusion: Considering the side effects associated with conventional therapies for RA and the drug resistance observed in some patients, alternative therapies such as MSCs may offer new opportunities for the management and treatment of this disease.

Highlights

Mohsen Ghoryani: Google Scholar, PubMed

Faeze Bagherifar: Google Scholar

Mojgan Mohammadi: Google Scholar, PubMed

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 43, Issue 822
2nd Week,, September
July and August 2025
Pages 804-818

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  • Receive Date: 02 February 2025
  • Accept Date: 01 October 2025

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