Relationship between Hyperuricemia and the Severity of Coronary Artery Involvement in Patients with Acute Coronary Syndrome

Document Type : Original Article(s)

Authors

1 Association Professor, Department of Cardiology, Islamic Azad University (Najafabad Branch), Najafabad, Iran

2 General Medicine, Islamic Azad University (Najafabad Branch), Isfahan, Iran

3 Assistant Professor, Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

4 Association Professor, Department of Emergency Medicine, Khatam-Al-Anbia Hospital, Zahedan University of Medical Sciences, Zahedan, Iran

10.48305/jims.v43.i819.0670

Abstract

Background: Given that the relationship between increased serum uric acid as a risk factor associated with cardiovascular diseases is still not clear. This study aimed to investigate the role of hyperuricemia in the severity of coronary artery involvement in patients with acute coronary syndrome.
Methods: The current cross-sectional study was conducted on 114patients with cardiovascular diseases who referred to the Heart Clinic and Emergency Department of Khorshid Hospital in Isfahan. At the beginning of the study, their basic and clinical information such as age, gender, comorbidity, severity of coronary artery involvement and number of involved vessels were recorded. Also, the occurrence of acute coronary syndromes was recorded. Then, the serum uric acid level was measured and recorded after 12hours of fasting. Hyperuricemia was defined as a serum uric acid level of more than 7.5mg/dl in men and more than 6.5mg/dl in women.
Result: The mean serum uric acid level of these patients was 4.8±1.5 mg/dl; so that 22(19.3%) were hyperuricemic and 92(80.7%) were without hyperuricemia. In female patients, the frequency of hyperuricemia was significantly higher than in males (54.5% vs. 17.4%; P<0.001). On the other hand, factors related to cardiovascular diseases such as severity of coronary artery involvement, number of involved vessels and coronary syndrome had no significant relationship with hyperuricemia(P>0.05).
Conclusion: According to the results of the present study, this study showed that serum uric acid level was not significantly associated with cardiovascular risk factors and severity of stenosis, number of involved vessels and type of coronary artery syndrome.

Highlights

Ahmad Mirdamadi: Google Scholar, PubMed

Ali Abdolrazaghnejad: Google Scholar, PubMed

Faezeh Tabesh: Google Scholar, PubMed

Keywords

Main Subjects

References

  1. Wang Q, Wen X, Kong J. Recent progress on uric acid detection: a review. Crit Rev Anal Chem 2020; 50(4): 359-75.
  2. Chen G, Shriner D, Doumatey AP, Zhou J, Bentley AR, Lei L, et al. Refining genome-wide associated loci for serum uric acid in individuals with African ancestry. Hum Mol Genet 2020; 29(3): 506-14.
  3. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 2007; 86(4): 899-906.
  4. Pascual EP, Perdiguero M. Gout, diuretics and the kidney. Ann Rheum Dis 2006; 65(8): 981–2.
  5. Lippi G, Montagnana M, Franchini M, Favaloro EJ, Targher G. The paradoxical relationship between serum uric acid and cardiovascular disease. Clinica Chimica Acta 2008; 392(1-2): 1-7.
  6. Wu AH, Gladden JD, Ahmed M, Ahmed A, Filippatos G. Relation of serum uric acid to cardiovascular disease. Int J Cardiol 2016; 213: 4-7.
  7. Gaubert M, Bardin T, Cohen-Solal A, Diévart F, Fauvel JP, Guieu R, et al. Hyperuricemia and hypertension, coronary artery disease, kidney disease: from concept to practice. Int J Mol Sci 2020; 21(11): 4066.
  8. Mohammed AQ, Abdu FA, Liu L, Zhang W, Yin G, Xu Y, et al. Hyperuricemia predicts adverse outcomes after myocardial infarction with non-obstructive coronary arteries. Front Med (Lausanne) 2021; 8: 716840.
  9. Saito Y, Tanaka A, Node K, Kobayashi Y. Uric acid and cardiovascular disease: a clinical review. J Cardiol 2021; 78(1): 51-7.
  10. Li S, Chen H, Zhou L, Cui H, Liang S, Li H. The uric acid to albumin ratio: a novel predictor of long-term cardiac mortality in patients with unstable angina pectoris after percutaneous coronary intervention. Scand J Clin Lab Invest 2022; 82(4): 304-10.
  11. Lim SS, Yang YL, Chen SC, Wu CH, Huang SS, Chan WL, et al. Association of variability in uric acid and future clinical outcomes of patient with coronary artery disease undergoing percutaneous coronary intervention. Atherosclerosis 2020; 297: 40-6.
  12. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971–1992. National Health and Nutrition Examination Survey. JAMA 2000; 283(18): 2404–10.
  13. Wei X, Zhang M, Huang S, Lan X, Zheng J, Luo H, et al. Hyperuricemia: a key contributor to endothelial dysfunction in cardiovascular diseases. FASEB J 2023; 37(7): e23012.
  14. Mogensen UM, Køber L, Jhund PS, Desai AS, Senni M, Kristensen SL, et al. Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM‐HF. Eur J Heart Fail 2018; 20(3): 514-22.
  15. Sekizuka H. Uric acid, xanthine oxidase, and vascular damage: potential of xanthine oxidoreductase inhibitors to prevent cardiovascular diseases. Hypertens Res 2022; 45(5): 772-4.
  16. Rampidis GP, Benetos G, Benz DC, Giannopoulos AA, Buechel RR. A guide for Gensini score calculation. Atherosclerosis 2019; 287: 181-3.
  17. Purnima S, Abd El-Aal BG. Serum uric acid as prognostic marker of coronary heart disease (CHD). Clin Investig Arterioscler 2016; 28(5): 216-24.
  18. Karimian B, Khademvatan K, Seyyed-Mohammadzad MH, Alinejad V, Abasnejad P, Noori F, et al. Evaluation of the associations between the severity of coronary heart disease and serum levels of uric acid or fetuina undergoing coronary angiography [in Persian]. Studies in Medical Sciences 2015; 26(8): 663-71.
  19. Nabati M, Shiran M, Esfahani Z, Yousefnejad K, Habibi V, Dabirian M, et al. Relationship between the Level of Serum Uric Acid and Severity of Coronary Artery Atherosclerosis Determined by Coronary Angiography in Patients with Chronic Stable Angina [in Persian]. J Mazandaran Univ Med Sci 2013; 22(98): 19-26.
  20. Tian TT, Li H, Chen SJ, Wang Q, Tian QW, Zhang BB, et al. Serum Uric Acid as an Independent Risk Factor for the Presence and Severity of Early‐Onset Coronary Artery Disease: A Case‐Control Study. Dis Markers 2018; 2018: 1236837.
Journal of Isfahan Medical School
Volume 43, Issue 819
3rd Week, August
July and August 2025
Pages 670-675

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History

  • Receive Date: 31 December 2024
  • Accept Date: 13 September 2025

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