Comparison of Arterial Blood Gases in Pressure-Controlled Ventilation and Volume-Controlled Ventilation Modes in Patients with Drug Poisoning

Document Type : Original Article(s)

Authors

1 MSc Student in Critical Care Nursing, Department of Medical-Surgical Nursing, School of Nursing, Gonabad University of Medical Sciences, Gonabad, Iran

2 Assistant Professor, Department of Medical-Surgical Nursing, School of Nursing, Gonabad University of Medical Sciences, Gonabad, Iran

3 Associate Professor, Department of Anesthesiology, School of Medicine, Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran

4 Student in Nursing, Student research committee, Gonabad University of Medical Sciences, Gonabad, Iran

5 Professor, Department of Medical-Surgical Nursing, School of Nursing, Nursing Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.

10.48305/jims.v43.i824.0859

Abstract

Background: Mechanical ventilation is one of the most critical interventions for patients with drug poisoning in intensive care units. This study aimed to compare arterial blood gases (ABG) between two modes of mechanical ventilation: pressure-controlled ventilation (PCV) and volume-controlled ventilation (VCV) in patients with drug poisoning.
Methods: This study is analytical-comparative research conducted in Tehran in 2023. The study sample included 120 patients with drug poisoning who were undergoing mechanical ventilation, selected through convenience sampling based on the inclusion criteria (60 patients in each group). ABG parameters were measured in the two study groups (PCV and VCV) before and one hour after the initiation of the ventilation mode. Data were analyzed, with a significance level of 0.05.
Findings: The findings revealed significant differences in pH, base excess (BE), and PCO₂ levels in the PCV group one hour after initiating the mode compared to baseline (P < 0.05). In both groups, PaO₂ and SpO₂ levels significantly increased one hour after the initiation of the mode compared to baseline (P < 0.05). However, there were no significant differences between the two groups regarding ABG parameters one hour after the initiation of the mode (P > 0.05).
Conclusion: The results of this study indicate that although PCV had better outcomes in some parameters, overall, there were no significant differences between PCV and VCV in terms of their effects on arterial blood gas parameters in patients with drug poisoning undergoing mechanical ventilation.

Highlights

Elias Hoseinzadeh: Google Scholar

Omid Moradi Moghaddam: Google Scholar

Moosa Sajadi: Google Scholar, PubMed

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 43, Issue 824
4th Week, September
September and October 2025
Pages 859-866

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History

  • Receive Date: 02 January 2025
  • Accept Date: 13 September 2025

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