Comparison of Topical 5% Nicotinamid and 2% Clindamycin Gels in the Treatment of the Mild to Moderate Acne Vulgaris: A Double-Blinded Randomized Clinical Trial

Document Type : Original Article (s)

Authors

1 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran AND Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Skin Diseases and Leishmaniasis Research Center AND Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Skin Diseases and Leishmaniasis Research center, Isfahan University of Medical Sciences, Isfahan, Iran

5 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Acne vulgaris is considered as one of the most common disorders for which, patients seek dermatologic care. In the current study, we evaluated the efficacy of the 5% nicotinamide gel versus 2% clindamycin gel in the treatment of the mild to moderate acne vulgaris.Methods: This randomized, controlled clinical trial was performed in 2009-2010. Sixty female patients with mild or moderate acne vulgaris were recruited to be treated either with 5% nicotinamide or 2% clindamycin gel for 8 weeks. Acne severity index (ASI) was used to evaluate the response to treatment and SPSS software was used to analyze the data.Findings: The mean of ASI at the baseline was 16.85 ± 8.50 and 18.20 ± 12.27 in nicotinamide and clindamycin groups, respectively (P > 0.0500). The mean of ASI was significantly decreased compared with baseline during the time in both groups (P < 0.0001). However, there was not any significant difference regarding reduction of ASI between the nicotinamide and clindamycin groups (P = 0.5830).Conclusion: Five percent nicotinamide gel is as effective as 2% clindamycin gel for treatment of mild to moderate acne vulgaris. No side effect was observed during the treatment. 

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 316 - Serial Number 316
November and December 2015
Pages 2279-2285

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History

  • Receive Date: 03 July 2014
  • Revise Date:
  • Accept Date: 06 April 2022

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