The Efficacy and Safety of Rotavirus Vaccine in Children under the Five Years of Age; Systematic Review and Meta-Analysis

Document Type : Review Article

Authors

1 Assistant Professor, Department of Community Medicine, School of Medical Education, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Associate Professor, Department of Community Medicine, School of Medicine AND Gastro-Intestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran

3 Associate Professor, Department of Pediatrics, Akbarabadi Hospital, Iran University of Medical Sciences, Tehran, Iran

4 Health Technology Assessment Office, Department of Standardization and Tariff, Deputy of Curative Affairs, Ministry of Health and Medical Education, Tehran, Iran

5 Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

6 Clinical Knowledge Management Unit, Department of Community Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Abstract

Background: Rotavirus infection is a common cause of acute gastroenteritis among uner-5-years-old children, especially in those countries which has not implemented a rotavirus vaccination program. The aim of this study was to estimate the safety and efficacy of Rotarix® and Rotateq® vaccines.Methods: We performed a systematic literature review in randomized controlled trials and quasi-experimental studies on children of general population. We searched Medline, Ovid, ISI, Cochrane, Proquest, Scopus, DARE, HTA and NHSEED databases. Meta-analysis was performed and we assessed heterogeneity using Q test and used random model for pooling estimate of efficacy of rotavirus vaccines (Rotarix® and Rotateq®). Publication bias was assessed via Egger’s and Begg’s tests.Findings: Twelve eligible studies were included in meta-analysis. The pooled estimate of vaccine efficacy for Rotarix® and Rotateq® was 80% (95% CI: 0.68-0.87) and 70% (95% CI: 0.65-0.85), respectively. Relative risk of side effects in vaccinated versus no-vaccinated groups was in the range of 0.83 to 1.2.Conclusion: The results show that vaccination against rotavirus prevented sever and none-severe diarrhea in children and could reduce burden of the disease. It is necessary to perform cost-effectiveness studies for implementing rotavirus vaccination in Iran.

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 303 - Serial Number 303
July and August 2014
Pages 1605-1622

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History

  • Receive Date: 08 February 2014
  • Revise Date:
  • Accept Date: 06 April 2022

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