Investigation of Diagnostic Value of Albumin in Predicting Improvement of Non-Alcoholic Fatty Liver Disease in Patients with Fatty Liver Disease Undergoing Bariatric Surgery

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

10.48305/jims.v43.i820.0695

Abstract

Background: Considering the importance of the diagnostic value of albumin in predicting the recovery of non-alcoholic fatty liver disease, this study was conducted with the aim of determining the diagnostic value of serum alevin in the recovery of non-alcoholic fatty liver disease in patients with fatty liver undergoing bariatric surgery.
Methods: In this prospective study, 112 patients underwent bariatric surgery, liver biopsy was performed during the operation, and fatty liver disease was determined in them. The level of serum albumin and the status of fatty liver disease were determined by ultrasound before and 1, 3 and 6 months after the operation. The amount of changes in serum albumin level in two groups with and without fatty liver disease and the diagnostic value criteria of albumin in predicting non-alcoholic fatty liver disease were determined with the result of liver biopsy.
Findings: According to liver biopsy results, 48.2% were patients with fatty liver. The average serum albumin level was 4.53 ± 0.77 before the operation and 3.31 ± 0.65 mg/dL six months after the operation and decreased by 25.53 ± 15.5 percent. The percentage of decrease in albumin level in patients with fatty liver was 17.67 ± 13% and in the non-affected group, it was 33.97±13.6% (P < 0.001). According to the findings of the rock diagram, the albumin cut-off point for predicting fatty liver is 3.5, and according to it, the albumin level has a sensitivity of 98.1%, a specificity of 37.9%, a positive predictive value of 59.6%, and a negative predictive value. 95.7% was obtained.
Conclusion: The serum albumin level in obese patients can be used as a preliminary test to determine the grade of fatty liver and also to determine the recovery status of fatty liver after surgery.

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Journal of Isfahan Medical School
Volume 43, Issue 820
4th Week, August
July and August 2025
Pages 695-702

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History

  • Receive Date: 17 June 2025
  • Accept Date: 19 July 2025

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