1
Assistant Professor of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences
2
Assistant of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences
3
Veterinarian, Torabi Nejad Research center, Isfahan University of Medical Sciences
Abstract
Post operative adhesion formation is a very important clinical problem because of its complications such as pain, bowel obstruction, infertility and subsequent intra-operative complications. We aimed to investigate the effects of melatonin (ME), as an agent acting against free radicals, on the prevention of adhesion formation. Background: A number of 39 rats were randomly assigned into three groups of equal number. Serosal injury was created using a standard technique, one group received a single dose of intraperitoneal (IP) ME immediately after injury; a single dose of subcutaneous (SC) ME was given to the second group 30 minutes prior to surgery; but the control group did not received ME. All animals were re-operated 2 weeks after the surgery and the adhesion scores were determined by an examiner blinded to the under experiment groups. Methods: The total score of adhesion reduced significantly in IP and SC groups in comparison to controls (p
Movahedi, M., Hajhashemy, M. & Adibi, S. (2007). Effect of Melatonin in the Prevention of Post-operative Adhesion Formation in an Experimental Study. (e13205). Journal of Isfahan Medical School, 25(87), e13205
MLA
Movahedi, M., Hajhashemy, M., & Adibi, S. "Effect of Melatonin in the Prevention of Post-operative Adhesion Formation in an Experimental Study" .e13205 , Journal of Isfahan Medical School, 25, 87, 2007, e13205.
HARVARD
Movahedi, M., Hajhashemy, M., & Adibi, S. (2007). 'Effect of Melatonin in the Prevention of Post-operative Adhesion Formation in an Experimental Study', Journal of Isfahan Medical School, 25(87), e13205.
CHICAGO
Movahedi, M., Hajhashemy, M. & Adibi, S., "Effect of Melatonin in the Prevention of Post-operative Adhesion Formation in an Experimental Study." Journal of Isfahan Medical School, 25 87 (2007): e13205,
VANCOUVER
Movahedi M., Hajhashemy M., Adibi S. Effect of Melatonin in the Prevention of Post-operative Adhesion Formation in an Experimental Study. JIMS. 2007;25(87):e13205 (In Persian).
