Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of Relative Frequency of Human Papillomatous Virus by Using of Immiunohistochemistry Method between Patients with Prostatic Adenocarcinoma or Benign Prostatic Hyperplasia

Document Type : Original Article(s)

Authors
Mojgan Mokhtari 1
Faegheh Taghizadeh 2
Esmaeil Rouzbahani 3
Tahmineh Narimani 4
1 Associate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Pathologist, Isfahan University of Medical Sciences, Isfahan, Iran.
3 Orthopedic Surgeon, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
Background: Prostatic Adenocarcinoma is the most prevalent cancer in men and cause of death in them. Many risk factors have been recognized like as Human Papillomatous Virus (HPV) which could be detected better by immiunohistochemistry (IHC) method. Our aim was comparing the relative frequency of HPV in patients with adenocarcinoma or benign prostatic hyperplasia (BPH).Methods: In this study, presence of HPV in 120 cases (90 with BPH and 30 with adenocarcinoma) was detected by IHC.Finding: As a whole, 4 patients (3 in adenocarcinoma and 1 in BPH group) were HPV positive (detected by IHC method). The mean age was in 61.75 and 68.51 years in HPV positive and HPV negative groups, respectively. Correlation between age and HPV was not significant. Correlation between HPV and adenocarcinoma was meaningful (P = 0.048).Conclusion: In this study, 3.3% of patients were HPV positive. HPV is a risk factor for prostat hyperplasia and also its conversion to malignancy. HPV infections shold be diagnosed and treated in early stages to reduce prevalence of adenocarcinoma and other complications.         
Keywords
Prostate
Human papillomatous virus
Benign prostatic hyperplasia
Adenocarcinoma
  1. Rosai J. Surgical Pathology. 9th ed. London: Mosby; 2004.
  2. Kumar V, Fausto N, Abbas A. Robbins and Co-tran. Pathologic Basic of Disease. 7th ed. Phila-delphia: WB. Saunders; 2004.
  3. Wideroff L, Schottenfeld D, Carey TE, Beals T, Fu G, Sakr W, et al. Human papillomavirus DNA in malignant and hyperplastic prostate tissue of black and white males. Prostate 1996; 28(2): 117-23.
  4. Howat AJ, Mills PM, Lyons TJ, Stephenson TJ. Absence of S-100 protein in prostatic glands. Histopathology 1988; 13(4): 468-70.
  5. Carozzi F, Lombardi FC, Zendron P, Confortini M, Sani C, Bisanzi S, et al. Association of hu-man papillomavirus with prostate cancer: analy-sis of a consecutive series of prostate biopsies. Int J Biol Markers 2004; 19(4): 257-61.
  6. Leiros GJ, Galliano SR, Sember ME, Kahn T, Schwarz E, Eiguchi K. Detection of human papil-lomavirus DNA and p53 codon 72 polymor-phism in prostate carcinomas of patients from Argentina. BMC Urol 2005; 5: 15.
  7. Gherdovich S, Barbacci P, Mitrione MP, Farina U, Muraro GB, Anichini M. Detection of the hu-man papillomavirus in hyperplastic and cancer-ous prostatic tissue with PCR. Minerva Urol Ne-frol 1997; 49(2): 73-7.
  8. Noda T, Sasagawa T, Dong Y, Fuse H, Namiki M, Inoue M. Detection of human papillomavirus (HPV) DNA in archival specimens of benign prostatic hyperplasia and prostatic cancer using a highly sensitive nested PCR method. Urol Res 1998; 26(3): 165-9.
  9. McNicol PJ, Dodd JG. Detection of papilloma-virus DNA in human prostatic tissue by Southern blot analysis. Can J Microbiol 1990; 36(5): 359-62.
  10. Allsbrook WC, Jr., Simms WW. Histochemistry of the prostate. Hum Pathol 1992; 23(3): 297-305.
  11. Howley PM, lowy DR. Papillomavirus. In: Knipe PM, Howley PM, editors. Fields Virology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2006. p. 2238-67.
Journal of Isfahan Medical School
Volume 29, Issue 127 - Serial Number 127
January and February 2011
Pages 80-85

  • Receive Date 17 April 2011
  • Accept Date 06 April 2022