1
Associate Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2
Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: APC is a tumor-suppressor protein. To evaluate the correlation between APC expression and pathogenesis of colorectal cancer, we investigated the expression of this protein in cancerous and normal colorectal tissues.Methods: APC expression was evaluated in 50 pairs of primary colorectal cancers and corresponding normal colorectal tissues using immunohistochemical staining on paraffin-embedded sections.Findings: APC was expressed in all tissues. It was down-regulated in the colorectal cancer specimens compared with the matched normal tissues (P < 0.001). Conclusion: APC expression may be a favorable biologic marker and a useful prognostic indicator in patients with colorectal cancer.
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Nikbakht Dastjerdi,M. and Mahmoodi,M. (2011). Comparative Analysis of APC Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry. Journal of Isfahan Medical School, 29(161), 1815-1821.
MLA
Nikbakht Dastjerdi,M. , and Mahmoodi,M. . "Comparative Analysis of APC Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry", Journal of Isfahan Medical School, 29, 161, 2011, 1815-1821.
HARVARD
Nikbakht Dastjerdi M., Mahmoodi M. (2011). 'Comparative Analysis of APC Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry', Journal of Isfahan Medical School, 29(161), pp. 1815-1821.
CHICAGO
M. Nikbakht Dastjerdi and M. Mahmoodi, "Comparative Analysis of APC Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry," Journal of Isfahan Medical School, 29 161 (2011): 1815-1821,
VANCOUVER
Nikbakht Dastjerdi M., Mahmoodi M. Comparative Analysis of APC Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry. JIMS, 2011; 29(161): 1815-1821.
