Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Antimicrobial Dose of Doxycycline on Glycemic Control in Patients with Diabetes and Moderate Periodontitis after the Phase 1 of Periodontal Treatment

Document Type : Original Article(s)

Authors
Mohammad Reza Naseh 1
Jamshid Poursamimi 1
Sima Hashemipour 2
Nazanin Zangeneh 3
1 Assistant Professor, Department of Periodontics, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran
2 Associate Professor, Department of Internal Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
3 Resident, Department of Pediatrics Dentistry, School of Dentistry, Islamic Azad University, Tehran Branch, Tehran, Iran
Abstract
Background: There are contradictory results of different studies about the effect of periodontal treatment on metabolic control of diabetes. Due to the importance of management of the patients, the purpose of this study was to examine the effect of periodontal therapy [scaling and root planning (SRP)] with doxycycline on glycemic control in patients with type 2 diabetes mellitus.Methods: In this double-blind randomized controlled clinical trial, 40 patients with type 2 diabetes mellitus who had moderate periodontitis were treated with scaling and root planning + placebo (SRP; n = 20) or with scaling and root planning + doxycycline 100 mg/day, for 21 days (SRP + Doxy; n=20). Periodontal parameters including bleeding on probing (BOP), clinical attachment loss (CAL), plaque index (PI), and probing depth (PD), also metabolic parameter (HbA1c) were recorded at baseline and 3 months after the treatment.Findings: After 3 month, all periodontal parameters and HbA1c showed significant improvement in both groups (P < 0.001). The reduction of all periodontal parameters and HbA1c was not significantly different between the groups in this study (P for BOP = 0.799; P for CAL = 0.667; P for PI = 0.253; P for PD = 0.989; and P for HbA1c = 0.301).Conclusion: Periodontal treatment with the adjunctive systemic doxycycline may influence the systemic conditions of patients with type 2 diabetes mellitus, but no statistical differences was observed between the control and treatment groups. Therefore, confirmatory studies with controlled diabetes are necessary.
Keywords
Diabetes Mellitus
Periodontal Disease
Doxycycline
Metabolic control
HbA1c
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Journal of Isfahan Medical School
Volume 32, Issue 274 - Serial Number 274
January and February 2014
Pages 102-109

  • Receive Date 13 October 2013
  • Accept Date 06 April 2022