Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of Prophylactic Antiemetic Effect of Ondansetron, Dexamethasone and Metoclopramide in Cesarean Delivery under General Anesthesia

Document Type : Original Article (s)

Authors
Hamidreza Bahmani 1
Seyed Ebrahim Sadeghi 1
Ladan Hosseinipanah 2
1 Assistant Professor, Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2 Student of Medicine, School of Medicine, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: Positive effectiveness of antiemetic drugs was approved in reduction of post-operative nausea and vomiting (PONV). The purpose of this study was comparison of dexamethazone, ondansetron and metoclopramide in prevention of post-operative nausea and vomiting.Methods: 210 women candidates for elective cesarean section under general anesthesia were divided in to three groups of 70. The groups received ondansetron, dexamethazone or metoclopramide near the end of the surgery. Post-operative nausea and vomiting was evaluated at 0, 2, 4 and 8 hours after the operation. The results were analyzed using Kruskal-Wallis test.Findings: Injection of all three drugs, ondansetron, metoclopramide and dexamethazane reduced post-operative nausea and vomiting. The rate of reduction of nausea and vomiting was significant in all 3 groups at 4 hours after the surgery. At this time, the dexamethazane group had the highest nausea and vomiting (P = 0.007).Conclusion: Ondansetron and metoclopramide can be used in the patients with elective cesarean section under general anesthesia for reduction of post-operative nausea and vomiting; the drugs showed more effectiveness with longer duration compared to dexamethasone.
Keywords
Cesarean section
Dexamethasone
Ondansetron
Metoclopramide
Nausea and vomiting
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Journal of Isfahan Medical School
Volume 33, Issue 330 - Serial Number 330
March and April 2015
Pages 505-514

  • Receive Date 10 December 2014
  • Accept Date 06 April 2022