Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Intravenous Therapy with Hypertonic Saline 5% (HTS) in Patients with High Intracranial Pressure, 24 and 48 Hours after the Surgery

Document Type : Original Article (s)

Authors
Mohammad Ali Attari 1
Gholam Reza Khalili 1
Amir Taheri 2
1 Associate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Increased intracranial pressure (ICP) can be life-threatening and is associated with poor prognosis. In these patients, mortality rate and life expectancy would increase by reducing the intracranial pressure. Finding appropriate way to reduce pressure without specific changes in blood electrolytes and blood pressure is essential. This study aimed to evaluate the effect of rehydration with hypertonic saline 5% on intraoperative complications and prognosis in patients with high intracranial pressure.Methods: This study was performed on 90 patients with high intracranial pressure undergone surgery. After skin incision, hypertonic saline 5% was injected intravenously. Electrolytes and vital signs of patients at baseline and at 24 and 48 hours after the surgery were compared. The data were analyzed using ANOVA with repeated measures test.Findings: 54 patients (60%) were men and 36 (40%) were women, with the mean age of 48.1 ± 9.8 years. Administration of hypertonic saline significantly increased sodium level (137.5 to 144.9 mmol/l), potassium level (3.8 to 4.96 mmol/l), the amount of output (1.43 to 3.94 l), systolic blood pressure (104.6 to 127.32 mmHg), diastolic blood pressure (61.58 to 85.13 mmHg) and anion gap (9.34 to 18.8) (P < 0.001 for all).Conclusion: This study showed that the use of hypertonic saline 5% serum in patients with high intracranial pressure who need surgery, improve the electrolyte and vital signs, especially blood pressure, which increases the quality of treatment and consequently reduces mortality rate of the patients.
Keywords
Intracranial pressure
Hypertonic saline
Prognosis
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Journal of Isfahan Medical School
Volume 33, Issue 367 - Serial Number 367
November and December 2016
Pages 2393-2399

  • Receive Date 05 October 2015
  • Accept Date 06 April 2022