Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Saffron Supplementation on Serum Matrix Metallopeptidase 9 (MMP9) and Ejection Fraction Following High Intensity Aerobic Training in Patients with Coronary Artery Bypass Graft Surgery

Document Type : Original Article (s)

Authors
Hossein Nik-Maleki 1
Neda Khaledi 2
Pezhman Motamedi 2
Hamid Rajabi 3
Khosro Minavand 4
1 PhD Student of Cardio-Respiratory Exercise Physiology, Department of Physical Education, School of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran
2 Assistant Professor, Department of Physical Education, School of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran
3 Associate Professor, Department of Physical Education, School of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran
4 Cardiologiest, Department of Cardiology, Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran
10.22122/jims.v36i469.9676
Abstract
Background: The purpose of this study was to evaluate the effect of saffron supplementation on matrix metallopeptidase 9 (MMP9) and ejection fraction following high intensity exercise in patients with coronary artery bypass graft (CABG).Methods: In this practical quasi-experimental study, about one month after their surgery, 30 patients were selected and randomly assigned to 2 groups. Exercise group in each session did two 10-minute sessions of intense periodic exercises and 15 seconds of activity with 100% peak power, 15 seconds of passive rest, and 4 minutes of rest between the two 10-minute sessions; the supplementation group more than exercises received daily 300 mg saffron supplement after lunch. ANOVA and Bonferron's post-hoc test were used to determine the difference and the location of the difference, respectively. All statistical analysis was done at the significant level of P < 0.050.Findings: The implementation of periodic exercises did not significantly increase the amount of matrix metallopeptidase 9 factor. Significant increase was seen in ejection fraction among exercise and supplementation groups compared to the control group (P < 0.050 for both).Conclusion: In this study, the results showed that periodic exercise did not significantly increase the level of matrix metallopeptidase 9. The increase was in the effective ejection fraction, which in improved the angiogenesis and blood discharges in patients after the coronary artery bypass graft surgery.
Keywords
Periodic exercise
Matrix Metalloproteinase 9
Ejection fraction
Saffron
Cardiac diseases
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Journal of Isfahan Medical School
Volume 36, Issue 469 - Serial Number 469
January and February 2018
Pages 176-183

  • Receive Date 16 February 2018
  • Accept Date 06 April 2022