Journal of Isfahan Medical School

Journal of Isfahan Medical School

Evaluation of Cholesterol Synthesis and Absorption Pathways in Patients with Cardiovascular Diseases

Document Type : Original Article (s)

Authors
Fahimeh Amirkhani 1
Gholamreza Namazi 2
Bentolhoda Hayatmoghadam 1
Morteza Pourfarzam 3
1 Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
3 Professor, Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences AND Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v37i523.11144
Abstract
Background: Nowadays, coronary artery diseases (CADs) are among the most common diseases in societies. The aim of this study was to study the interplay between cholesterol absorption and synthesis in two groups of Iranian patients with CAD by measuring the markers of cholesterol synthesis and absorption pathways in plasma.Methods: The study population included 128 patients undergoing clinically indicated coronary angiography. Patients were divided into two groups after scoring the severity of their coronary stenosis; the S-stenosis group (patients with CAD, n = 75) had a significant stenosis indicated by coronary angiography, and the second group, N-stenosis (n = 55), had no significant coronary stenosis. Fasting plasma samples were used to measure cholesterol absorption and synthesis markers by gas chromatography-mass spectrometry (GC-MS).Findings: The level of cholesterol absorption markers in patients with coronary artery stenosis was slightly increased compared to patients without coronary artery stenosis, but this change was statistically significant only for cholestanol (P < 0.050). In terms of cholesterol synthesis markers, the results did not show any significant differences between the two groups (P > 0.050 for all).Conclusion: Study of cholesterol synthesis and absorption markers has not been reported in Iranian patients before. This article reports the results of such study for the first time. Considering the high prevalence of CADs and the importance of cholesterol metabolism in pathology of these diseases, the results may be used to understand some underlying mechanisms of development and progression of these diseases, and to manage the patient better.
Keywords
Coronary artery stenosis
Cholesterol
Gas chromatography-mass spectrometry
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Journal of Isfahan Medical School
Volume 37, Issue 523 - Serial Number 523
March and April 2019
Pages 385-391

  • Receive Date 13 December 2018
  • Accept Date 06 April 2022