Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold Nanoparticles

Document Type : Original Article (s)

Authors
Marziyeh Mirzaeiyan 1
Ahmad Shanei 2
Hossein Hejazi 3
1 PhD Student, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Professor, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v37i531.11968
Abstract
Background: Acoustic cavitation, which occurs at high intensities of ultrasound waves, can be fatal for tumor cells. On the other hand, the existence of nanoparticles in a liquid decreases the acoustic cavitation onset threshold. In this study, the combined effects of ultrasound and gold nanoparticles on breast carcinoma tumor model in BALB/c mice were studied.Methods: The tumor-bearing mice were divided into 4 groups of control, gold nanoparticles, ultrasound, and ultrasound in the presence of gold nanoparticles. Therapeutic effects on tumors were evaluated by measuring relative tumor volume, doubling time, and 5-folding time for tumor volume.Findings: The 5-folding time showed a significant difference between ultrasound in the presence of the gold nanoparticles and the other groups. The maximum doubling and 5-folding times were found in the ultrasound in the presence of gold nanoparticles group.Conclusion: Combined effects of ultrasound and gold nanoparticles can be used as a method for increasing the efficiency of the treatment of carcinoma tumors.
Keywords
Breast tumors
Gold
Nanoparticle
Ultrasound waves
  1. Liu Q, Wang X, Wang P, Xiao L. Sonodynamic antitumor effect of protoporphyrin IX disodium salt on S180 solid tumor. Chemotherapy 2007; 53(6): 429-36.
  2. Marmottant P, Hilgenfeldt S. Controlled vesicle deformation and lysis by single oscillating bubbles. Nature 2003; 423(6936): 153-6.
  3. Tang H, Wang CC, Blankschtein D, Langer R. An investigation of the role of cavitation in low-frequency ultrasound-mediated transdermal drug transport. Pharm Res 2002; 19(8): 1160-9.
  4. Sazgarnia A, Shanei A. Evaluation of Acoustic cavitation in terephthalic acid solutions containing gold nanoparticles by the spectrofluorometry method. INT J Photoenergy 2012; 2012: 376047.
  5. Paciotti GF, Myer L, Weinreich D, Goia D, Pavel N, McLaughlin RE, et al. Colloidal gold: A novel nanoparticle vector for tumor directed drug delivery. Drug Deliv 2004; 11(3): 169-83.
  6. Kim KH, Kim JK, Lee DH. Sonodynamic induced antitumor effect of Radachlorin on solid tumor. Curr Appl Phys 2011; 11(3): 559-63.
  7. Shanei A, Attaran N, Mirzaeiyan M, Salamat MR, Hejazi H. Cancerous cell destruction using low level ultrasound in the presence of gold nanoparticles: An in vitro study on 4T1 cells. Curr Nanosci 2018; 14(4): 329-34.
  8. Patra HK, Banerjee S, Chaudhuri U, Lahiri P, Dasgupta AK. Cell selective response to gold nanoparticles. Nanomedicine 2007; 3(2): 111-9.
  9. Sazgarnia A, Shanei A, Taheri AR, Meibodi NT, Eshghi H, Attaran N, et al. Therapeutic effects of acoustic cavitation in the presence of gold nanoparticles on a colon tumor model. J Ultrasound Med 2013; 32(3): 475-83.
Journal of Isfahan Medical School
Volume 37, Issue 531 - Serial Number 531
May and June 2019
Pages 667-672

  • Receive Date 23 June 2019
  • Accept Date 06 April 2022