Journal of Isfahan Medical School

Journal of Isfahan Medical School

Evaluation of the Relation between Serum Level of High-Sensitivity Reactive Protein (HS-CRP) and Coronary Calcification with the Presence of Coronary Artery Disease in Computed Tomography Angiography

Document Type : Original Article (s)

Authors
Amirreza Sajjadieh 1
Alireza Arefpour 2
1 Assistant Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v37i531.11277
Abstract
Background: Some studies showed that two factors of calcium score and high-sensitivity C-reactive protein (HS-CRP) are related with coronary artery disease, but no definitive theory has been provided. The aim of this study was to determine the relationship between serum level of HS-CRP and calcium score with coronary artery disease.Methods: In a cross-sectional study, 200 patients who were candidates for computed tomography (CT) angiography were studied. The level of HS-CRP and coronary artery calcium scores were measured and their correlation with the intensity of coronary artery disease were evaluated.Findings: There was a direct and significant correlation between calcium score and HS-CRP level (r = 0.25, P < 0.001). Multivariate analyzes showed that the odds ratio of coronary artery disease was 3.5 fold more for male sex, 3.7 fold for smokers, 7.6 fold for positive family history, 5.8 fold for high blood pressure, 1.4 fold for calcium scores, 11.8 f fold or high HS-CRP, 1.8 fold for hyperlipidemia.Conclusion: Our results show that HS-CRP level in patients with coronary artery disease is higher than those without coronary artery disease, and there is a direct and significant correlation between this index and calcium scores. HS-CRP seems to be a good indicator for predicting the risk of coronary disease. At the same time, further studies in this field are suggested.
Keywords
C-Reactive Protein
Vascular calcification
Coronary Disease
Computed Tomography Angiography
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Journal of Isfahan Medical School
Volume 37, Issue 531 - Serial Number 531
May and June 2019
Pages 673-679

  • Receive Date 19 January 2019
  • Accept Date 06 April 2022