Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Rosuvastatin on Prevention of Contrast-Induced Acute Kidney Injury in Patients with Chronic Kidney Disease

Document Type : Original Article (s)

Authors
Firouzeh Moeinzadeh 1
Mohammad-Saleh Jafarpishe 2
Marzieh Rezaee 3
1 Assistant professor, Department of Nephrology, School of Medicine AND Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant professor, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v38i589.13364
Abstract
Background: Contrast-induced acute kidney injury (CI-AKI) is an important issue in patients who are candidate for using contrast media in order to do diagnostic and therapeutic imagining. This study aimed to investigate the effect of rosuvastatin on the development of contrast-induced acute kidney injury in patients with chronic kidney disease performing computed tomography (CT) scan with contrast media.Methods: In this clinical trial study, 402 patients with chronic kidney disease who underwent CT scan with contrast in Alzahra hospital, Isfahan, Iran, during the years 2018-2019 were studied. Patients were divided into two groups, patients in the first group received 20 mg rosuvastatin 24 hours prior to CT scan and 10 mg rosuvastatin tablets daily for two consecutive days. The second group received the placebo.Findings: There was a significant difference in creatinine and glomerular filtration rate (eGFR) after CT scan (P < 0.050). The mean of creatinine was lower, and the mean of eGFR was higher in the intervention group than placebo after the intervention (P < 0.050). The frequency of contrast-induced acute kidney injury in the intervention group was 1%, and in the placebo group was 4% (P = 0.059).Conclusion: Rosuvastatin can reduce the risk of contrast-induced acute kidney injury after using contrast media, including increase in creatinine, and decrease in eGFR.
Keywords
Acute Kidney Injury
Chronic kidney disease
Contrast Agent
Glomerular filtration rate
Creatinine
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Journal of Isfahan Medical School
Volume 38, Issue 589 - Serial Number 589
July and August 2020
Pages 628-633

  • Receive Date 24 August 2020
  • Accept Date 06 April 2022