Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Correlation between Coronary Artery Calcium Score with Diagnosis of Angina Pectoris in Patients with and without Metabolic Syndrome, Candidates for Coronary Angiography

Document Type : Original Article (s)

Authors
Parvin Bahrami 1
Fakhredin Mohammad Moosaie 2
Amirreza Sajjadieh 3
Jalal Karimi 4
Alireza Nematollahi 1
1 Assistant Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Internal Specialist Assistant, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Epidemiologist, Department of Social Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v40.i689.0759
Abstract
Background: The coronary artery calcium score is a reliable measure of coronary atherosclerosis. This study evaluated the relationship between coronary artery calcium score, cardiovascular events, and metabolic syndrome.
Methods: This cross-sectional study was performed in Al-Zahra Hospital in 2019 and included patients who referred to the emergency department of Al-Zahra Hospital with a complaint of typical and atypical chest pain and admitted to the emergency ward of the hospital. Those with a pre-test probability between 5-15 percent underwent coronary CT angiography and their coronary calcium score was calculated and recorded. The data were analyzed using Mantel-Haenszel Chi-square statistical tests of two domains and correlation test (Bivariate Correlations).
Findings: The correlation between metabolic syndrome and coronary artery calcium score was meaningful. The odds ratio of men with metabolic syndrome with a coronary artery calcium score was about 4 times higher than women. After adjusted for gender by Mantel-Haenszel method, the chance of developing metabolic syndrome and coronary artery calcium score of 1 or above was 9.96. With bivariate correlations test, the correlation between coronary artery calcium score and metabolic syndrome was statistically significant.
Conclusion: Coronary artery calcium score is more common in patients with metabolic syndrome (MetS) and these are two valuable predictors for coronary artery disease.
Keywords
Atherosclerosis
Cardiovascular diseases
Metabolic syndrome
Coronary artery disease
  1. Shreya D, Zamora DI, Patel GS, Grossmann I, Rodriguez K, Soni M, et al. Coronary artery calcium score - A reliable indicator of coronary artery disease? Cureus 2021; 13(12): e20149.
  2. Vecsey-Nagy M, Szilveszter B, Kolossváry M, Boussoussou M, Vattay B, Merkely B, et al. Correlation between coronary artery calcium-and different cardiovascular risk score-based methods for the estimation of vascular age in caucasian patients.
    J Clin Med 2022; 11(4): 1111.
  3. Zeb I, Budoff M. Coronary artery calcium screening: Does it perform better than other cardiovascular risk
    stratification tools? Int J Mol Sci 2015; 16(3): 6606-20.
  4. Blaha MJ, Mortensen MB, Kianoush S, Tota-Maharaj R, Cainzos-Achirica M. Coronary artery calcium scoring: Is it time for a change in methodology? JACC Cardiovasc Imaging 2017; 10(8): 923-37.
  5. Taylor AJ, Bindeman J, Feuerstein I, Le T, Bauer K, Byrd C, et al. Community-based provision of statin and aspirin after the detection of coronary artery calcium within a community-based screening cohort. J Am Coll Cardiol 2008; 51(14): 1337-41.
  6. Budoff MJ, Young R, Lopez VA, Kronmal RA, Nasir K, Blumenthal RS, et al. Progression of coronary calcium and incident coronary heart disease events.
    J Am Coll Cardiol 2013; 61(12): 1231-9.
  7. Gunn J, Taggart Transcatheter versus surgical intervention: lessons from trials of coronary revascularisation. Heart 2019; 105(Suppl 2): s44-9.
  8. Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 2010; 56(14):
    1113-32.
  9. Shreya D, Zamora DI, Patel GS, Grossmann I, Rodriguez K, Soni M, et al. Coronary artery calcium score - A reliable indicator of coronary artery
    disease? Cureus 2021; 13(12): e20149.
  10. Greenland P, Blaha MJ, Budoff MJ, Erbel R, Watson KE. Coronary calcium score and cardiovascular risk. J Am Coll Cardiol 2018, 72(4): 434-47.
  11. Fudim M, Zalawadiya S, Patel DK, Egolum UO, Afonso L. The metabolic syndrome, coronary artery calcium score and cardiovascular risk reclassification. Int J Cardiol 2016; 204: 81-2.
  12. Kempton HR, Bemand T, Bart NK, Suttie JJ. Using coronary artery calcium scoring as preventative health tool to reduce the high burden of cardiovascular disease in indigenous australians. Heart Lung Circ 2020; 29(6): 835-39.
Journal of Isfahan Medical School
Volume 40, Issue 689
1st Week, December
November and December 2022
Pages 759-765

  • Receive Date 14 September 1401