Journal of Isfahan Medical School

Journal of Isfahan Medical School

Investigating a Variant in the Vitamin D Receptor Gene in Ahvaz Male and Female Athletes Compared to the Control Group with Normal Body Mass

Document Type : Original Article (s)

Authors
Maryam Hakimian 1
Delbar Mohammadi 1
Atousa Moradzadegan 2
1 MSc Student, Department of Experimental Sciences, Dezful Branch, Islamic Azad University, Dezful, Iran
2 Assistant Professor, Department of Experimental Sciences, Dezful Branch, Islamic Azad University, Dezful, Iran
10.48305/jims.v40.i692.0851
Abstract
Background: Typically 20-80% of changes in sports performance traits are related to genetic factors. To date, more than 200 genes related to sports performance have been identified. The VDR (Vitamin D receptor) gene can play an important role in cell proliferation, differentiation, and contraction process. The aim of this study is to investigate a variant of the VDR gene in athletes as a genetic marker in determining sports talent.
Methods: In this research, 100 professional athletes in 2 groups, men and women and 100 healthy non-athletes with normal BMI were included in the study as a control group. After obtaining informed consent, blood was drawn to determine the genotype of rs10735810 polymorphism or FokI locus by ARMS-PCR method. Data analysis was done with GraphPad Prism 6 software and the Chi-squared test.
Findings: The number of people with the F/F genotype in the athletes’ group was 23% and in the control group was 65%, as well as the people with the F/f genotype in the athletes’ group was 64% and in the control group was 20%. The number of people with the f/f genotype in two the athletes group was 13% and the control group was 15%. Also, no significant difference was observed from the comparison of genotypic frequency in the two groups of female and male athletes compared to each other.
Conclusion: This study showed that the effect of the f allele is only in the heterozygous state which indicates the gender-independent effect of this polymorphism in the population.
Keywords
FokI
Polymorphism
VDR
Gene
Athletes
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Journal of Isfahan Medical School
Volume 40, Issue 692
4th Week, December
November and December 2022
Pages 851-856

  • Receive Date 07 August 1401
  • Revise Date 28 September 1401
  • Accept Date 19 September 1401