Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Linalool, Cineole, Beta bourbonin and Aerobic Exercises as Protective Approaches in Mice with Alzheimer's Disease

Document Type : Original Article (s)

Authors
Zainab Alimoradi 1
Farzaneh Taghian 2
Khosro Jalali Dehkordi 2
1 PhD Candidate, Department of Sports Physiology, School of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
2 Associate Professor, Department of Sports Physiology, School of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
10.48305/jims.v41.i711.0148
Abstract
Background: : Alzheimer's disease is a progressive neurological disorder associated with aging. The aim of this research was to determine the effect of eight weeks of aerobic exercise and the consumption of linalool, cineol and beta bourbonin on the prevention and improvement of the cognitive process of mice with Alzheimer's disease.
Methods: 48 C57BL/6 female mice with an average age of 15 months were randomly divided into 8 groups of 6 each. Bioactive compounds including linalool with a concentration of 5.2 mg/kg, cineole with 100 mg/kg, beta bourbonin with a concentration of 72 mg/kg, were administered by gavage, and moderate-intensity aerobic exercise for 8 weeks. Bioinformatics analysis of Bdnf, Ngf and Creb genes were selected and measured by qPCR-Real Time.
Findings: The expression of Bdnf, Ngf and Creb increased in the Alzheimer+ bioactive compounds, Alzheimer+ aerobic exercise and Alzheimer+ bioactive compounds + aerobic exercise compared to the Alzheimer group. Aerobic exercises and consumption of bioactive compounds before the induction of Alzheimer's disease enhance Bdnf, Ngf, and Creb, indicating a protective effect in Alzheimer's disease. A synergistic effect was observed in the group of bioactive compounds + aerobic exercise + Alzheimer on the expression of genes compared to other groups.Additionally, the rate of new object recognition in the Alzheimer + bioactive compounds + aerobic exercise group was increased compared to other groups.
Conclusion: The decrease in Bdnf, Ngf, and Creb gene expression in the bioactive compounds+aerobic exercise+Alzheimer group was slighter than in other groups, indicating a protective effect on the process of Alzheimer's disease.
Keywords
Alzheimer’s disease
Bioinformatics
Exercise
Bdnf
Bioactive compounds
Subjects
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Journal of Isfahan Medical School
Volume 41, Issue 711
3rd Week, May
May and June 2023
Pages 148-158

  • Receive Date 11 February 2023
  • Accept Date 13 March 2023