Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Comparison of Two Different Doses of Mannitol on Creatine Phosphokinase (CPK) Reduction in Brain-Death Patients Who Candidates for Organ Donation: A Clinical Trial Study

Document Type : Original Article (s)

Authors
Parviz Kashefi 1
Seyed Arash Mirsattari 2
Armindokht Shahsanaei 3
Maryam Khalifesoltan 4
1 Professor, Department of Anesthesia, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Resident, Department of Anesthesia, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Assistant Professor, Department of Anesthesia, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 General Practitioner, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v41.i739.0896
Abstract
Background: The aims of this study were to compare the effects of two doses of 0.4 and 0.6 mg/kg mannitol on the rate of diuresis, residual renal function, hemodynamic changes and creatine phosphokinase changes in brain death patients.
Methods: In a single-blind randomized clinical trial study on brain death patients hospitalized in the intensive care units of Al-Zahra Hospital in Isfahan, 30 brain death patients were divided into two groups of 15, the first group was given 0.4 g/kg mannitol and the second group was given 0.6 g/kg mannitol with 1 mEq of sodium bicarbonate per kg for 20 minutes. And these values were repeated up to three times every 8 hours. Creatine phosphokinase levels were measured 8 hours after each dose of mannitol and urinary output 2 and 8 hours after each dose of mannitol and renal function, 8 hours after the last dose, and the mean changes were compared between the two groups.
Findings: Mean changes in serum creatine phosphokinase level were significantly decreased in the two groups, but the rate of reduction was not significantly different between the two groups. Glomerular filtration rate was significantly increased in both groups, but the rate of change was not different between the two groups. Also, changes in urinary output were significantly different between the two groups.
Conclusion: The use of 0.6 g / kg of mannitol is not superior to the dose of 0.4 g / kg of this drug in improving renal function and reducing creatinine phosphokinase levels.
Keywords
Brain death
Creatine phosphokinase
Glomerular filtration rate
Hemodynamic monitoring
Mannitol

Subjects

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Journal of Isfahan Medical School
Volume 41, Issue 739
3rd Week, December
November and December 2023
Pages 896-904

  • Receive Date 19 June 2023
  • Accept Date 04 November 2023