Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of the Effect of Modified and Conventional Hemofiltration and the Combination of Both Methods During Coronary Artery Bypass Graft Surgery (CABG) on Kidney Function

Document Type : Original Article(s)

Authors
Ghazal Homayoon 1
Alireza Hosseini 2
Maryam Nasiriyan 3
Mehrdad Khodarahmi 4
Razieh Khodsiani 5
Mehran Shahzamani 6
1 MSc Student in Circulatory Technology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor of Cardiovascular Surgery, Department of Surgery, Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Department of Epidemiology and Biostatics, Health School and Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Certified Nurse, Cardiovascular Perfusionist, Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
5 MSc in Cardiovascular Perfusion, Cardiovascular Perfusionist, Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
6 Associate Professor of Cardiovascular Surgery, Department of Surgery, Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v43.i804.0087
Abstract
Background: While coronary artery surgery is a particular medical procedure, it can impact other organs, such as the kidneys. As such, this study seeks to compare the effects of hemofiltration, two new and prevalent methods, and a combination of the two methods during cardiopulmonary bypass surgery on kidney function.
Methods: This study was a clinical trial that involved 60 patients undergoing cardiopulmonary bypass in the open-heart surgery room of Chamran Hospital, Isfahan. The study utilized a three-arm and double-blind randomized approach with an easy and accessible sampling method. The three intervention methods tested were common ultrafiltration, modified ultrafiltration, and a combination. The data was analyzed with a significance level of 5%.
Findings: The serum creatinine mean (SD) of patients in the intervention group increased by 1.15 (± 0.20) within the initial 24 hours after surgery, compared to the mean value of 1.02 (± 0.10) before surgery. In the common method, the mean glomerular filtration rate (± standard deviation) decreased in the first 24 hours after surgery compared to its mean value before surgery, which was 66.74 (± 8.95).
Conclusion: Changing the method of ultrafiltration has no impact on kidney function. The reduction in 24-hour drainage volume was more effectively achieved through either a novel method alone or a combination of two methods compared to the conventional method alone.

Highlights

Mehran Shahzamani: PubMed

Keywords
Bypass surgery
Coronary artery
Hemofiltration
Kidney

Subjects

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Haider A, Khwaja IA, Gull S, Nabi H, Khan I, Rehman HU. Zero balance versus conventional hemofiltration-impact on renal function and blood conservation in adult valvular cardiac surgery. Pakis J Med and Health Sci 2021; 15(9): 2314-8

Journal of Isfahan Medical School
Volume 43, Issue 804
4th Week, April
March and April 2025
Pages 87-94

  • Receive Date 20 April 2024
  • Accept Date 17 February 2025