Journal of Isfahan Medical School

Journal of Isfahan Medical School

Paradoxical Effects of Adenovirus 36 in the Development of Obesity and Body Metabolic Conditions

Document Type : Letter to Editor

Authors
Majid Karandish 1
Ali Teimoori 2
Mansour Siavash 3
Fatemeh Shirani 4
1 Professor, Nutrition and Metabolic Diseases Research Center, and Paramedical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Assistant Professor, Department of Virology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Professor, Endocrine and Metabolism Research Center of Isfahan. Isfahan University of Medical Sciences, Isfahan, Iran
4 Assistant Professor, Endocrine and Metabolism Research Center of Isfahan. Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v43.i805.0112
Abstract
Background: Viral infections, especially adenovirus 36 (Ad-36) infection, are considered an important factor in the development of obesity. The effects of Ad-36 infection are contradictory. On the one hand, Ad-36 infection leads to weight gain and fat accumulation, increased inflammation, and entry of macrophages into fat cells, causing obesity. On the other hand, it leads to reduced insulin resistance, improved lipid profile, and glycemic control. These effects may partly explain the variability in individual responses to antidiabetic drugs such as metformin and pioglitazone. Moreover, Ad-36 infection may potentially influence the development of new antidiabetic drugs. Further studies in this field are necessary.

Highlights

Majid Karandish: Google Scholar, PubMed

Ali Teimoori: Google Scholar 

Mansour Siavash: Google Scholar 

Fatemeh Shirani: Google Scholar, PubMed

Keywords
Adenovirus 36
Obesity
Metabolic disorder

Subjects

  1. Ponterio E, Gnessi L. Adenovirus 36 and Obesity: An Overview. Viruses. 2015;7(7):3719-40.
  2. Atkinson RL, Dhurandhar NV, Allison DB, Bowen RL, Israel BA, Albu JB, Augustus AS. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int J Obes (Lond). 2005;29(3):281-6.
  3. Shirani F, Teimoori A, McAinch AJ, Rashno M, Latifi SM, Karandish M. Human adenovirus 36 improves insulin sensitivity and lipid profiles and increases inflammatory markers in Wistar rats. J Investig Med. 2020;68(5):980-4.
  4. Dubuisson O, Dhurandhar EJ, Krishnapuram R, Kirk-Ballard H, Gupta AK, Hegde V, et al. PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cells. Endocrinology. 2011;152(10):3648-60.
  5. Tapia-Rivera JC, Mendoza-Jaramillo HE, González-Villaseñor CO, Ramirez-Flores M, Aguilar-Velazquez JA, López-Quintero A, et al. Effect of Human Adenovirus 36 on Response to Metformin Monotherapy in Obese Mexican Patients with Type 2 Diabetes: A Prospective Cohort Study. Viruses. 2023;15(7).
Journal of Isfahan Medical School
Volume 43, Issue 805
1st Week, May
May and June 2025
Pages 112-114

  • Receive Date 24 July 2024
  • Accept Date 17 February 2025