Journal of Isfahan Medical School

Journal of Isfahan Medical School

Study Serum Concentration of BP180 Glycoproteins in Multiple Sclerosis Patients and in Control Group in AL Zahra Hospital

Document Type : Original Article(s)

Authors
Azar Baradaran 1
Muhammadamin Sirojidinzoda 2
1 Professor of Pathology, Department of Pathology, School of Medicine, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v43.i838.1461
Abstract
Background: Multiple sclerosis is an autoimmune disease in which a demyelination process occurs, leading to disorders of nerve signal transmission. Researchers identified a significant relationship between neurological diseases and serum glycoprotein concentrations. In this regard, this study aimed to determine the serum concentration of glycoprotein BP180 in patients with multiple sclerosis and in the control group at Al-Zahra Hospital (S).
Methods: In this cross-sectional study conducted in 1401 at the Isfahan Super specialty Hospital, 70 participants were enrolled and divided into two groups of MS patients (40 people) and a healthy control group (30 people). A researcher-made questionnaire was provided to them, collecting information related to age, past disease history, etc. Then, BP180 autoantibody was tittered using Euro immunoassay kits (made in Europe) by ELISA. Independent t-test and chi-square were used to analyze the data.
Findings: Mean BP180 level was measured as 33.22 IU/dL in the case group and 11.91 IU/dL in the control group. BP180 level was significantly higher in the MS group. (P<0.0001).
Conclusion: Overall, our results in favor to most of articles reports that BP180 autoantibody is significantly higher in MS patients rather than the normal population. This may be the possible explanation for the strong association of MS and BP.

Highlights

Azar Baradaran: Google Scholar

Keywords
BP-180 glycoprotein
Multiple Sclerosis
Bullous pemphigoid

Subjects

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Journal of Isfahan Medical School
Volume 43, Issue 838
2nd Week, January
January and February 2026
Pages 1461-1464

  • Receive Date 21 April 2025
  • Accept Date 31 August 2025