Journal of Isfahan Medical School

Journal of Isfahan Medical School

The effect of Chamomile extract during endurance training on the levels of blood glucose and the hippocampus DCX protein in rats with type 1 diabetes

Document Type : Original Article(s)

Author
Vahid Valipour Dehnou
Sports Sciences Department, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran
10.48305/jims.v44.i851.0143
Abstract
Background: The effects of chamomile extract and endurance training on the improvement of some diabetes indices have been determined, but their effect on blood glucose and hippocampal DCX has not been investigated. Therefore, this study aimed to investigate the effect of chamomile extract during endurance training on blood glucose and hippocampal DCX protein in rats with type 1 diabetes.
Methods: Thirty adult male rats were divided into control (C), diabetes (D), diabetes-endurance training (DT), diabetes-chamomile extract (DS), and diabetes-chamomile extract- endurance training (DTS) groups. Training performed five sessions/w for eight weeks. Blood glucose and hippocampal DCX protein were measured.
Findings: Blood glucose of all groups was significantly higher than C group (p=0.001). Blood glucose in DT, DS and DTS groups was significantly lower than D group (p=0.001). But, blood glucose in DS group was lower than DT group (p=0.001). Also, the blood glucose of the DTS group was significantly lower than DT and DS groups (p=0.001). However, DCX protein of all groups was significantly lower than C group (p=0.001). Also, DCX protein of DS and DTS groups was significantly greater than D group (p<0.05). However, DCX protein of DT and DS groups was not significantly different (p=0.95). But, DCX protein of DT and DS groups was significantly lower than DTS group (p=0.001).
Conclusion: The interaction effect of chamomile and training was greater than their effect alone on glucose and DCX. Therefore, it is suggested that chamomile be consumed during training to enhance their effects on glucose and hippocampal DCX protein.

Highlights

Vahid Valipour Dehnou: Google Scholar: 

Keywords
Type 1 diabetes
Endurance training
Chamomile extract
DCX protein

Subjects

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Journal of Isfahan Medical School
Volume 44, Issue 851
3rd Week, April
March and April 2026
Pages 143-149

  • Receive Date 24 May 2025
  • Accept Date 15 May 2026