Journal of Isfahan Medical School

Journal of Isfahan Medical School

Prevalence of histopathological features of gastric biopsies in a referral hospital

Document Type : Original Article (s)

Authors
Maryam Derakhshan, 1
Marzieh Derakhshan 2
Pegah Hedayat 1
Samaneh Sadeghi 3
1 Assistant Professor, Department of Pathology, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor of Reproductive Biology, Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v44.i857.0479
Abstract
BACKGROUND: Gastrointestinal endoscopy and the acquisition of tissue samples are essential for the diagnosis and treatment of various gastric problems. Prevalence of different biopsy findings have been evaluated in former studies but few studies have been performed in Iran. Here we aimed to investigate and evaluate the results of gastric biopsies in Isfahan, Iran.
METHODS: This is a longitudinal cross-sectional study that was performed in 2020 on reports of gastric biopsies performed in 2013-2018. A total number of 500 gastric biopsies were selected based on inclusion and exclusion criteria. Data regarding age and gender of patients were gathered. Reports of gastric biopsies were also collected and studied. All data were analyzed using Independent Samples and Chi-Square analysis tests.
RESULTS: 66.4% of cases had gastritis and 28.4% had gastropathy. Intestinal metaplasia was more common in males (P= 0.002) and in higher ages (P< 0.001). Helicobacter Pylori and chronic gastritis were higher in lower ages (P= 0.01 and P= 0.001 respectively). A total number of 11 patients (2.2%) had benign lesions in their gastric biopsy report and 15 patients (3%) had adenocarcinoma that was significantly more prevalent in higher ages (P= 0.001).
CONCLUSION: Gastritis and intestinal gastropathy are most prevalent pathological findings in gastric biopsies. The prevalence rate of H-pylori infection, intestinal metaplasia, benign and malignant lesions were in line with the findings of previous studies.

Highlights

Maryam Derakhshan: Google Scholar

Marzieh Derakhshan: Google Scholar

Pegah Hedayat: Google Scholar

Keywords
Gastric Biopsy
Benign
Malignant
Gastritis
Subjects
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Journal of Isfahan Medical School
Volume 44, Issue 857
1st Week, June
May and June 2026
Pages 479-485

  • Receive Date 30 April 2025
  • Accept Date 07 September 2025