Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of the Efficacy of Ketamine-Metoclopramide and Acetaminophen-Metoclopramide Combinations on Pain Intensity After Deep Vitrectomy Surgery

Document Type : Original Article (s)

Authors
Darioush Moradi Farsani 1
Moslem Vahabi 2
1 Professor, Department of Anesthesiology, School of Medicine, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 General Physician, Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v44.i857.0497
Abstract
Introduction: Deep vitrectomy is a specialized ophthalmic surgery, and due to its invasive nature, effective post-operative pain management is of significant importance. The aim of this study was to compare the preemptive effect of two drug combinations, ketamine–metoclopramide and acetaminophen–metoclopramide, on pain intensity following deep vitrectomy and to evaluate patients’ need for analgesic medication.
Methods: In a randomized clinical trial, 120 patients scheduled for deep vitrectomy were allocated into three groups. Post-surgery, patients received one of the studied drug combinations or standard care (control group). Pain intensity was recorded using the VAS scale at specific time intervals. Demographic data, hemodynamic parameters, recovery duration, and patient satisfaction were also documented. Data were analyzed using Chi-square tests, one-way ANOVA, and repeated measures ANOVA with SPSS version 24. A P-value less than 0.05 was considered statistically significant.
Findings: There were no significant differences among the three groups regarding age, sex, BMI, hemodynamic status, and patient satisfaction. The mean post-operative pain intensity was significantly lower in the ketamine–metoclopramide group compared to the other two groups. Furthermore, the requirement for supplemental analgesics showed a notable decrease in this group.
Conclusion: The use of the ketamine–metoclopramide combination can be considered an effective choice for short-term pain relief after deep vitrectomy, demonstrating superior performance in reducing pain intensity and the need for analgesics compared to the acetaminophen–metoclopramide combination and standard care.

Highlights

Darioush Moradi Farsani: Google Scholar

Moslem Vahabi: Google Scholar

Keywords
Ketamine
Acetaminophen
Metoclopramide
Postoperative Pain
Vitrectomy
Subjects
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Journal of Isfahan Medical School
Volume 44, Issue 857
1st Week, June
May and June 2026
Pages 497-503

  • Receive Date 22 April 2026
  • Accept Date 01 June 2026