The Effect of Tranexamic Acid on Traumatic Brain Hematomas

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Hematoma is the most serious complication of head trauma and if we are capable to prevent the increment in size of hematoma, not only the mortality and morbidity but also the need of surgical intervention will decrease in management of head trauma. The aim of this study was to evaluate the effect of Tranexamic acid on traumatic brain hematomas.Methods: In a double blind clinical study, 190 head injured patients in whom the primary brain Computed tomography scan (CT scan) had confirmed the existence of one of the different kinds of hematoma were selected and randomly divided in two groups, the first group received Tranexamic acid and the second group received placebo (normal saline). For all patients another brain CT scan was performed 24 hour after receiving the medication for detecting new bleeding or a change in size of the previously existing hematoma and the CT scans were reported by an expert radiologist. The collected data was analyzed by SPSS software.Findings: Before the intervention the mean volume of the hematoma in the case and control group was 4.7 ± 4.9 and 5.0 ± 4.2, respectively and there was not statistically difference between the two groups (P = 0.64). The mean change in the volume of hematoma after intervention in the case and control group was -0.01 ± 3.71 and -0.13 ± 2.48, respectively and no statistically significant difference between the two groups were observed but considering the type of hematoma, the study showed meaningful decrease in the size of brain contusions in the case group.Conclusion: The effect of Tranexamic acid in traumatic brain injuries depends on the type of the lesion so that its effect on brain contusions was more prominent, although further studies are recommended to determine the overall effect of medication.

Keywords

References

  1. Winn H. Youmans Neurological Surgery. 6th ed. Philadelphia, PA: Elsevier; 2011. p. 3270, 3272.
  2. Roberts I, Shakur H, Ker K, Coats T. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev 2012; 12: CD004896.
  3. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376(9734): 23-32.
  4. Perel P, Al-Shahi SR, Kawahara T, Morris Z, Prieto-Merino D, Roberts I, et al. CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial. Health Technol Assess 2012; 16(13): iii-54.
  5. Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). BMJ 2011; 343: d3795.
Journal of Isfahan Medical School
Volume 34, Issue 381 - Serial Number 381
March and April 2016
Pages 478-483

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History

  • Receive Date: 20 January 2016
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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