Comparative Study of Apo-Lipoprotein(a) and High-Density Lipoprotein Levels in Patients Under Coronary Angiography with Obstructive and Non-Obstructive Stenosis

Document Type : Original Article(s)

Authors

1 Resident of Cardiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

2 Associate Professor, Department of Cardiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: The purpose of this study is to compare the relationship between patients with coronary artery disease and lipid profile changes in Shariati Hospital during the years 2017-2019.
Methods: The present study is a cross-sectional study that was conducted during 2017 -2019 at Dr. Shariati Hospital in Tehran on patients with vascular stenosis. Basic information and history of diseases such as high blood pressure and hyperlipidemia were obtained from patients' records. The lipid profile of the patients was measured, including cholesterol, triglyceride, lipoprotein Apoa (a), and HDL, and then compared between the two groups.
Findings: In this study, 332 patients with coronary artery stenosis were included in the study, based on angiography results, 169 patients had non-obstructive coronary artery stenosis and 163 patients had obstructive coronary artery stenosis. There was no significant difference in the mean level of lipid profile, including cholesterol, Low-density lipoprotein (LDL), High-density lipoprotein (HDL), triglycerides, and apolipoproteins Apo (a) and Apo (b) in patients with obstructive and non-obstructive coronary artery stenosis, while the level of lipoprotein (a) was higher in patients with obstructive coronary artery stenosis. (P = 0.001).
Conclusion: According to the present study, an independent association was found between lipoprotein A and increased risk of coronary artery disease. Therefore, this index can be used to predict coronary artery disease and start or intensify preventive treatments. More studies in this field are recommended.

Highlights

Arimeh Moradi Masihi: Google Scholar, PubMed

Shahin Shirani: Google Scholar

Seyed Abdolhosein Tabatabaei: Google Scholar, PubMed

Abbas Mohagheghi: Google Scholar, PubMed

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 41, Issue 747
3rd Week, February
January and February 2024
Pages 1096-1103

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History

  • Receive Date: 15 November 2023
  • Accept Date: 16 April 2024

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