Topical Fluconazole Combined with Local Glucantime Injection Compared with Local Glucantime Injections in Treatment of Leishmaniasis

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Medical Student, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: Leishmaniasis is one of the 6th important infectious diseases in the world that has been certificated as an endemic disease in Iran. The aim of this study was comparison of two methods of treatment included flouconazole with glucantime and glucantime alone in treatment of leishmaniosis.Methods: In this double blind prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were enrolled and randomized in to two groups. Fifty patients (group A) treated with topical flouconazole twice daily along with intralesional of glucantime once weekly until complete healing of the ulcer of for maximum of 6 weeks and fifty patients (group B) were treated with topical placebo twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer of for maximum of 6 weeks, The patients were followed for three months.Finding: In group A, 32 (64%) patients had complete cure whereas in the group B, 19 (38%) patients achieved complete cure with significantly difference (P < 0.001).Conclusion: The efficacy of foluconazole along with glucantime is more than placebo along glucontime in the treatment of cutaneous leshmaniasis. Also Fluconazale decrease the time of healing and the dose of glucantime that is needed for the treatment of cutaneous leshmaniasis.Future studies are warranted.Keywords: Leishmaniasis, Glucantime, Fluconazole

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Journal of Isfahan Medical School
Volume 28, Issue 118 - Serial Number 118
November and December 2011
Pages 1281-1289

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History

  • Receive Date: 19 March 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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