The Relative Frequency of Biopsy Diagnosed Renal Diseases in Patients with Renal Transplantation

Document Type : Original Article(s)

Authors

1 Associate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Renal transplantation is the treatment of choice for patients with end stage renal disease (ESRD). In cases of ant graft dysfunction at any time after transplantation, kidney biopsy is the golden standard for diagnosis. Kidney biopsies are categorized according to the Banff classification. This study aimed to evaluate the frequency of different allograft biopsies.Methods: In this cross-sectional study, the renal allograft biopsies obtained in both Alzahra and Noor in Isfahan, centers during the years 2006 to 2008 were studied based on Banff classification. The information and data were obtained from the department of pathology. When the data were completely gathered, they were analyzed via SPSS software.Finding: From 161 specimens, 68% were men and 32% were women. 85% of the grafts were from living unrelated donors, 9.9% from cadaver and 5% from living related donors. The relative frequencies of pathology diagnosis of biopsies were as 13.7% Tubular atrophy and interstitial fibrosis (TA &IF) grade II, 9.9% TA &IF III, 6.8% Acute rejection (AR) IA, 5.6% AR IB, 5% infarction, 5% borderline, 4.3% AR IIA, 4.3% TA&IF I, 3.7% antibody rejection and 1.9% AR IIB; also 44.7% had unrelated pathology to rejection. The greatest mean age for the patients under biopsy was for TA&IF I (45.5 years) and the smallest was for acute tubular necrosis (ATN) (24 years). The greatest mean time for biopsy was for TA&IF III (2666.2 days after biopsy) and the smallest was for ATN (72.8 days after biopsy).Conclusion: A great number of studies on renal allograft pathologies have been done in different transplant centers around the world. No studies have been done on pathologies in Alzahra and Khorshid hospitals in Isfahan which are referral centers for transplantation. This study can give us a picture of the major causes of graft dysfunction in our country according to race, environment and...

Keywords

References

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Journal of Isfahan Medical School
Volume 28, Issue 114 - Serial Number 114
September and October 2011
Pages 879-884

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History

  • Receive Date: 03 March 2011
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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