The Relationship between Thyroid Hormones with ST-segment Resolution in Patients with STEMI Who Underwent Primary Percutaneous Intervention

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Cardiology, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2 General Cardiologist, Tabriz Madani Heart Hospital, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

3 Interventional Cardiologist, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Background: Recently, researchers have become more interested in the role of thyroid hormones in acute coronary syndromes. In the present study, the serum levels of thyroid hormones in STEMI patients at the time of hospital admission and the it's correlation in the success rate in primary percutaneous intervention which is depicted in the form of ST-resolution was evaluated.
Methods: In this study, 500 patients who underwent primary angioplasty in Shahid Madani Tabriz hospital within early 2016 and late 2017 were included. The participants were divided in two groups: group 1 (decrease in
ST-resolution less than 50%) and group 2 (decrease in ST-RESOLUTION more than 50%). Correlations between thyroid hormones, ST resolution, mortality and Major Adverse Cardiovascular Events (MACE) were assessed.
Findings: The mean age of the patients was 57.22 ± 11.32 years old while 401 patients (80.2%) were male and 99 patients (19.8%) were female. In 152 patients (30.4%) ST resolution was 50% and less (group 1) and in 348 patients (69.6%) ST-RESOLUTION was more than 50%. No significant correlation was found between TSH and FT3 levels and ST resolution. Also, MACE and thyroid hormones didn’t have any correlation.
Conclusion: The finding of the present study showed there was no significant relationship between ST resolution and MACE and FT4, TSH and FT3 levels.

Keywords

References

  1. Grais IM, Sowers JR. Thyroid and the heart. Am J Med 2014; 127(8): 691-8.
  2. Wang WY, Tang YD, Yang M, Cui C, Mu M, Qian J, et al. Free triiodothyronine level indicates the degree of myocardial injury in patients with acute ST-elevation myocardial infarction. Chin Med J (Engl) 2013; 126(20): 3926-9.
  3. Kim DH, Choi DH, Kim HW, Choi SW, Kim BB, Chung JW, et al. Prediction of infarct severity from triiodothyronine levels in patients with ST-elevation myocardial infarction. Korean J Intern Med 2014; 29(4): 454-65.
  4. Pantos C, Mourouzis I, Saranteas T, Clavé G, Ligeret H, Noack-Fraissignes P, et al. Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion? Basic Res Cardiol 2009; 104(1): 69-77.
  5. Chen YF, Bhatia S, Redetzke R, Coburn T, Gerdes AM. Thyroid hormone improves left ventricular myocyte remodeling after myocardial infarction in rats. J Card Fail 2009; 15(6): S73.
  6. Friberg L, Drvota V, Bjelak AH, Eggertsen G, Ahnve S. Association between increased levels of reverse triiodothyronine and mortality after acute myocardial infarction. Am J Med 2001; 111(9): 699-703.
  7. Zhang B, Peng W, Wang C, Li W, Xu Y. A low fT3 level as a prognostic marker in patients with acute myocardial infarctions. Intern Med 2012; 51(21): 3009-15.
  8. Pingitore A, Chen Y, Gerdes AM, Iervasi G. Acute myocardial infarction and thyroid function: new pathophysiological and therapeutic perspectives. Ann Med 2012; 44(8): 745-57.
  9. Liu Q, Clanachan AS, Lopaschuk GD. Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts. Am J Physiol 1998; 275(3): E392-9.
  10. Bredy C, Ministeri M, Kempny A, Alonso-Gonzalez R, Swan L, Uebing A, et al. New York Heart Association (NYHA) classification in adults with congenital heart disease: relation to objective measures of exercise and outcome. Eur Heart J Qual Care Clin Outcomes 2018; 4(1): 51-8.
  11. Brozaitiene J, Mickuviene N, Podlipskyte A, Burkauskas J, Bunevicius R. Relationship and prognostic importance of thyroid hormone and N-terminal pro-B-Type natriuretic peptide for patients after acute coronary syndromes: a longitudinal observational study. BMC Cardiovasc Disord 2016; 16(1): 45.
  12. Jankauskienė E, Orda P, Barauskienė G, Mickuvienė N, Brožaitienė J, Vaškelytė JJ, et al. Relationship between left ventricular mechanics and low free triiodothyronine levels after myocardial infarction: a prospective study. Intern Emerg Med 2016; 11(3): 391-8.
  13. Qari FA. Thyroid hormone profile in patients with acute coronary syndrome. Iran Red Crescent Med J 2015; 17(7): e26919.
  14. Satar S, Seydaoglu G, Avci A, Sebe A, Karcioglu O, Topal M. Prognostic value of thyroid hormone levels in acute myocardial infarction: just an epiphenomenon? Am Heart Hosp J 2005; 3(4): 227-33.
  15. Seo SM, Koh YS, Park HJ, Kim DB, Her SH, Lee JM, et al. Thyroid stimulating hormone elevation as a predictor of long‐term mortality in patients with acute myocardial infarction. Clin Cardiol 2018; 41(10): 1367-73.

Reindl M, Feistritzer HJ, Reinstadler SJ, Mueller L, Tiller C, Brenner C, et al. Thyroid-stimulating hormone and adverse left ventricular remodeling following
ST-segment elevation myocardial infarction. Eur Heart J Acute Cardiovasc Care 2019; 8(8): 717-26.

Journal of Isfahan Medical School
Volume 40, Issue 664
4th Week, May
May and June 2022
Pages 165-171

Files

History

  • Receive Date: 04 June 2022
  • Accept Date: 04 June 2022

Share

How to cite

Statistics