A Comparison on the Preventive Effect of 100 mg and 200 mg Oral Celecoxib on Shivering during and after Orthopedic Lower Extremity Surgery under the Spinal Anesthesia; A Randomized Controlled Clinical Trial Study

Document Type : Original Article (s)

Authors

1 Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract

Background: This study aimed to compare the anti-shivering effects of 100 mg and 200 mg oral celecoxib with control group undergoing orthopedic lower extremity surgeries under spinal anesthesia.Methods: In a randomized double-blinded clinical trial study that was conducted at Ayatollah Kashani hospital in Isfahan, Iran, the patients undergoing elective orthopedic surgery of the lower extremity under spinal anesthesia with class 1 stage based on the American Society of Anesthesiologists (ASA) scale, were evaluated. The first group received placebo tablets, the second group received 100 mg oral celecoxib, and the third group received 200 mg oral celecoxib 3 hours prior to spinal anesthesia. Incidence and intensity of shivering was compared 10 minutes after the anesthesia, and every 15 minutes until the end of surgery in all three groups.Findings: A significant difference was observed between the three groups at all periods of time (P < 0.05). The group receiving 200 mg celecoxib experienced the less shivering.Conclusion: A dose of 200 mg oral celecoxib was reported to be more effective on shivering during and after the orthopedic lower extremity surgery in patients under spinal anesthesia as compared to 100 mg oral celecoxib and the control group.

Keywords

References

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Journal of Isfahan Medical School
Volume 38, Issue 564 - Serial Number 564
January and February 2020
Pages 67-73

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History

  • Receive Date: 02 November 2018
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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