Role of Pro564Leu of FXIII-A Gene Polymorphism and Risk of Central Nervous Bleeding in Patients with Congenital Factor XIII Deficiency, Southeast of Iran

Document Type : Original Article (s)

Authors

1 Associate Professor, Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

2 Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

3 Assistant Professor, Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

4 Professor, Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

5 Associate Professor, Department of Health Care Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

6 Department of Hematology, School of Medicine, Tarbiat Modares University, Tehran, Iran

Abstract

Background: The deficiency of factor XIII is a rare hemorrhagic disorder with the highest global incidence in Sistan and Baluchistan province in Iran. Bleeding of central nervous system (CNS) is a common but life-threatening clinical presentation of severe factor XIII deficiency. The aim of this study was to assess the role of Pro564Leu polymorphism in occurrence of intra- and extra-cranial hemorrhage in factor 13 deficiency.Methods: 32 patients with factor XIII deficient and history of CNS bleeding and 32 patients with factor XIII deficiency but without CNS bleeding were selected as case and control groups. Initially, the baseline for the Trp187Arg polymorphism was evaluated in both groups to confirm the disorder. Then, all the patients were assessed for Pro564Leu polymorphism.Findings: All the study patients were homozygote for factor XIII polymorphism. We also found that no patient in both groups was positive for Pro564Leu polymorphism.Conclusion: It seems that Pro564Leu polymorphism do not have any effect on occurrence of CNS bleeding in factor XIII deficiency.

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 272 - Serial Number 272
January and February 2014
Pages 25-33

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History

  • Receive Date: 08 October 2013
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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