Investigating the Effect of a Period of Intense Interval Training on the Expression of Genes Involved in Calcium Flow in the EDL Muscle of Diabetic Rats

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Physical Education, School of Literature and Humanities, Vail-E-Asr University of Rafsanjan, Rafsanjani, Iran

2 Assistant Professor, Department of Anesthesiology, School of Medicine, Rafsanjani University of Medical Sciences, Rafsanjani, Iran

3 MSc, Department of Physiology, School of Literature and Humanity, Islamic Azad University of Kerman, Kerman, Iran

Abstract

Background: Diabetic neuropathy (DN) leads to the initiation of several pathways, including oxidative stress and destruction of small vessels, as well as the destruction of factors involved in the SR network of muscle. The purpose of this research was to investigate the effect of the high intensity interval training on the expression of genes involved in calcium flow in the EDL muscle of diabetic rats.
Methods: The current research was experimental development study. In total, 48 male rats were randomly divided into 4 groups: training diabetes, diabetes, training and control group. The training group performed the interval training program for 4 weeks and 5 sessions per week. Each training session on the treadmill lasted for 44 minutes. The statistical test of two-way variance (two-way ANOVA) was used for analyzing the data.
Findings: High intensity interval training led to a non-significant decrease in Stim1 gene expression. And there was a significant decrease in the expression of Orai and MG29 genes in the long extensor digitorum muscle of male rats.
Conclusion: It is possible HIIT training is able to modulate the expression disorder of Orai, MG29, and Stim1 in diabetes, which may be due to various mechanisms such as controlling oxidative stress factors and growth factors. It seems it exerts its beneficial effects on the Side-effects of diabetes.

Keywords

References

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Journal of Isfahan Medical School
Volume 40, Issue 685
1st Week, November
November and December 2022
Pages 659-666

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History

  • Receive Date: 17 May 1401
  • Revise Date: 24 May 1401
  • Accept Date: 10 July 1401

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