Predictive Factors of Seizures in Patients with Organophosphate Poisoning

Document Type : Original Article (s)

Authors

1 Professor, Isfahan Clinical Toxicology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine AND Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Poisoning with organophosphate (OP) compounds is common and causes many complications, including seizure. The purpose of this study was to investigate the predictor factors of seizure in patients with organophosphate poisoning.Methods: This study was performed on patients with organophosphate poisoning hospitalized from 2007 to 2015 in university referral hospital in Isfahan City, Iran. Patients' information including age, sex, seizure, time between ingestion and admission to hospital, vital signs, duration of connection to ventilator, blood glucose, and blood pH were evaluated. The different variables were compared between patients with and without seizure. Binary logistic regression was used for determining variables for prediction of seizure.Findings: 209 patients with organophosphate poisoning were evaluated during the study period. Patients’ mean age was 33.1 ± 18.4 years (range: 2-90 years). Most of the patients were men (61.2%). The prevalence of seizure in patients was 5.7%, which was more common in patients with miosis (33.3% vs. 13.7%, P = 0.040). Patients with seizure required more intubation and longer periods of ventilation (5.1 ± 3.2 vs. 0.9 ± 0.4 days, P < 0.001). There was no significant difference between patients with and without seizure with respect to other variables. 27 patients died, of whom 3 patients had seizure. None of the above variables were predictive for seizure.Conclusion: The results of this study showed that the prevalence of seizure in patients with organophosphate poisoning was 5.7%. Seizure was more common in those with miosis. Length of ventilation was more in patients with seizure.

Keywords

References

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Journal of Isfahan Medical School
Volume 35, Issue 458 - Serial Number 458
November and December 2018
Pages 1738-1743

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History

  • Receive Date: 20 November 2017
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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