Evaluation of Epidemiologic, Clinical and Laboratory Findings of COVID-19 Patients in Intensive Care Units, Alzahra Hospital

Document Type : Original Article (s)

Authors

1 Professor, Anesthesiology and Critical Care Research Center, Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 PHD in Information science and Epistemology, Alzahara Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

5 General Practitioner, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Considering the high burden of the COVID-19 disease and the pressure that was put on the health care system, especially in the intensive care unit (ICU), the examination of variables predicting the outcome of this disease can help in better understanding of patients at risk and more useful allocation of limited resources.
Methods: Patients with COVID-19 hospitalized in the ICU of Al-Zahra Medical Center were investigated in an observational (descriptive-analytical) study. Demographic, clinical, and laboratory findings were compared to find factors affecting mortality between two groups of deceased and survived patients. A comparison of demographic, clinical, and laboratory findings was conducted to identify factors influencing mortality rates in deceased and survived patients.
Findings: 1144 patients with COVID-19 were examined in the study, of which 674 were men (58.9%) and 470 were women (41.1%). The patients were split into two groups: 432 patients (37.8%) died, and 712 patients (62.2%) survived. The variables of white blood cells (P < 0.001), neutrophil (P < 0.001), neutrophil to lymphocyte ratio (P = 0.004), blood urea nitrogen (P < 0.001), creatinine (P = 0.037), procalcitonin (P < 0.001), D-dimer (P < 0.001), length of hospitalization (P < 0.001) and oxygen therapy (P < 0.001) were directly related with mortality and the highest odd ratio was related to neutrophil count (OR = 3.59). Variables of lymphocyte
(P = 0.028), eosinophil (P < 0.001), hemoglobin (P < 0.001), platelet (P = 0.007), sodium (P < 0.001), potassium (P < 0.001), magnesium (P < 0.001), prothrombin time (P < 0.001), respiratory rate group (P < 0.022) and respiratory symptom (P < 0.032) were inversely related to mortality and the lowest odd ratio was related to magnesium (OR = 0.01).
Conclusion: Examining clinical and laboratory characteristics helps us in better evaluation of patients, recognition of risk factors involved in the progression of the disease, and better management of patients.

Highlights

Saeed Abbasi: Google Scholar, PubMed

Parviz Kashefi: Google Scholar

Soodabeh Rostami: Google Scholar, PubMed

Behjat Taheri: Google Scholar

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 41, Issue 751
3rd Week, March
March and April 2024
Pages 1209-1218

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History

  • Receive Date: 05 November 2022
  • Accept Date: 28 April 2024

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