Effect of Hydroalcoholic Extract of Cinnamomum on Strychnine-Induced Seizure in Mice

Document Type : Original Article (s)

Authors

1 Student of Medicine, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran

2 Assistant Professor, Department of Physiology and Pharmacology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

3 Assistant Professor, Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran

4 Student, Sama Technical and Vocational Training College, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran

5 Associate Professor, Department of Chemistry, School of Sciences, University of Kurdistan, Sanandaj, Iran

6 Assistant Professor, Department of Neurology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Abstract

Background: Seizure is defined as abnormal electrical discharges of neurons in central nervous system (CNS) that leads to a temporary dysfunction of brain. Cinnamomum is an herbal medicine used in Chinese and Indian alternative medicine as a sedative agent. This study aimed to investigate the effect of hydroalcoholic extract of Cinnamomum on strychnine-induced seizure.Methods: Forty male mice weighting 25-35 g, were randomly selected and divided into 5 groups of 8. The animals received either extract vehicle [dimethyl sulfoxide (DMSO) + saline], cinnamomum hydroalcoholic extract (100, 200 or 400 mg/kg) or diazepam (10 mg/kg), as the positive control, intraperitoneally. In all groups, thirty minutes later, strychnine (1.5 mg/kg) was injected and the seizure latency and duration and the mortality rate were registered.Findings: The seizure latency significantly delayed in animals treated with 200 or 400 mg/kg of cinnamomum extract compared to the control. In addition, the seizure attacks reduced by 25% and 37.5% in animals received 200 or 400 mg/kg of the extract, respectively. The above treatment reduced strychnine-induced mortality compared to the control group.Conclusion: We found that hydroalcoholic cinnamomum extract could prevent the strychnine-induced seizure.

Keywords

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Journal of Isfahan Medical School
Volume 32, Issue 299 - Serial Number 299
July and August 2014
Pages 1388-1395

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History

  • Receive Date: 14 May 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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