Antispasmodic Effect of Hydroalcoholic Extracts of Rosemary and Lavender on Rat Isolated Uterus Contractions

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: In traditional medicine, Lavender and Rosemary are referred as antispasmodic agents. However, so far their direct effects on uterus contraction have not been reported. This study aimed to assess antispasmodic effect of hydroalcoholic extracts of rosemary and lavender on rat isolated uterus contractions.Methods: In this research, the relaxant effect of hydroalcoholic extracts of these plants on rat isolated uterus contraction induced by KCl, acetylcholine, oxytocin, and electrical field stimulation (EFS) was determined and compared with nifedipine.Findings: Hydroalcoholic extracts of Lavender and Rosemary inhibited uterus contractions induced by KCl, acetylcholine, oxytocin, and EFS in a concentration-dependent manner.Conclusion: Hydroalcoholic extracts of Lavender and Rosemary have relaxant effects on uterus smooth muscle, and can be useful in prevention of premature labor.

Keywords

References

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Journal of Isfahan Medical School
Volume 37, Issue 546 - Serial Number 546
September and October 2020
Pages 1136-1142

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History

  • Receive Date: 24 September 2019
  • Revise Date:
  • Accept Date: 06 April 2022

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