The Effect of Vitamin D Supplementation on Serum Level of Insulin-Like Growth Factor 1 (IGF-1) in 5-10-Years-Old Children with Idiopathic Short Stature

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Professor, Department of Pediatrics, School of Medicine AND Imam Hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Idiopathic short stature is a common cause for referral to children's endocrinology clinics. Despite the normal level of growth hormone, the level of insulin-like growth factor 1 (IGF-1) is low in some of these individuals, which is not well-defined. The aim of this study was to determine the effect of vitamin D on the level of IGF-1 in children aged 5 to 10 years with idiopathic stunting.Methods: In a clinical trial study, 30 children aged 5-10 years with the diagnosis of idiopathic short stature were selected, and treated with 50000 vitamin D3 supplements every week for 8 weeks. Serum levels of vitamin D and IGF-1 were measured before and after intervention and compared.Findings: Before and after intervention, mean serum levels of vitamin D were 17.03 ± 6.8 and 44.4 ± 9.2 ng/ml (P < 0.001), and mean serum level of IGF-1 were 17.9 ± 81.5 and 124.4 ± 37.4 ng/ml (P < 0.001), respectively. The level of IGF-1 significantly increased by vitamin D supplementation.Conclusion: The present study showed that improvement of vitamin D deficiency led to increased level of IGF-1. It seems that in children with idiopathic short stature, the elimination of vitamin D deficiency can be effective in increased level of IGF-1.

Keywords

References

  1. Lee B, Kwon CY, Jang S. Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children: A protocol for systematic review and network meta-analysis. Medicine (Baltimore) 2020; 99(43): e22856.
  2. Zhao Q, Zhang M, Ji B, Chu Y, Pan H, Yan W, et al. Relationship between hemoglobin and insulin-like growth factor-1 in children and adolescents with idiopathic short stature. BMC Endocr Disord 2020; 20(1): 119.
  3. Saki F, Dabbaghmanesh MH, Omrani GR, Bakhshayeshkaram M. Vitamin D deficiency and its associated risk factors in children and adolescents in southern Iran. Public Health Nutr 2017; 20(10): 1851-6.
  4. Trummer C, Schwetz V, Pandis M, Grubler MR, Verheyen N, Gaksch M, et al. Effects of vitamin D supplementation on IGF-1 and calcitriol: A randomized-controlled trial. Nutrients 2017; 9(6): 623.
  5. Pollak MN, Schernhammer ES, Hankinson SE. Insulin-like growth factors and neoplasia. Nat Rev Cancer 2004; 4(7): 505-18.
  6. Wahl DA, Cooper C, Ebeling PR, Eggersdorfer M, Hilger J, Hoffmann K, et al. A global representation of vitamin D status in healthy populations. Arch Osteoporos 2012; 7: 155-72.
  7. Muscogiuri G, Annweiler C, Duval G, Karras S, Tirabassi G, Salvio G, et al. Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke. Int J Cardiol 2017; 230: 577-84.
  8. Ameri P, Giusti A, Boschetti M, Bovio M, Teti C, Leoncini G, et al. Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency. Eur J Endocrinol 2013; 169(6): 767-72.
  9. Soliman AT, Al KF, Alhemaidi N, Al AM, Al ZM, Yakoot K. Linear growth in relation to the circulating concentrations of insulin-like growth factor I, parathyroid hormone, and 25-hydroxy vitamin D in children with nutritional rickets before and after treatment: endocrine adaptation to vitamin D deficiency. Metabolism 2008; 57(1): 95-102.
  10. Bogazzi F, Rossi G, Lombardi M, Tomisti L, Sardella C, Manetti L, et al. Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects. J Endocrinol Invest 2011; 34(8): e200-e203.
  11. Saremi A, Shavandi N, Vafapour H. Eight-week resistance training with vitamin D supplementation in postmenopausal women: Effects on skeletal muscle. Pejouhandeh 2013; 18(2): 57-63. [In Persian].
  12. Yaghmaie B, Sayarifard F, Modarresi M, Mohammadpour M, Sharifzade M, Hassani A, et al. Investigation of serum 25 hydroxy vitamin D level in critically ill children and its relation with demographic and clinical risk factors. biome Res 2017; 28(5): 2120-5.
  13. Hypponen E, Boucher BJ, Berry DJ, Power C. 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: A cross-sectional study in the 1958 British Birth Cohort. Diabetes 2008; 57(2): 298-305.
  14. Martin JA, Ellerbroek SM, Buckwalter JA. Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins. J Orthop Res 1997; 15(4): 491-8.
Journal of Isfahan Medical School
Volume 39, Issue 651 - Serial Number 651
November and December 2022
Pages 901-905

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History

  • Receive Date: 12 September 2021
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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