Is There Any Difference in the Levels of Antibodies against Helicobacter Pylori Infection between the Patients with Migraine Headache with or without Aura?

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences AND Department of Pharmacology, School of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran

3 Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Recent studies have focused on a positive correlation between Helicobacter pylori (H. pylori) infection and occurrence of migraine headache. This study aimed to determine the role of H. pylori infection in the two common types of migraine headache including with (MA) and without aura (MO).Methods: In a case-control study, 84 patients (with MA or MO migraine headache) and 49 healthy individuals were enrolled. The enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of immunoglobulin G (IgG) and M (IgM) against H. Pylori in patients and controls.Findings: The mean age was 35.8 ± 11.1 and 33.4 ± 18.9 years in patient and control groups, respectively. The mean level of IgM antibody was significantly more in patients (26.3 ± 23.1 U/ml) compared to control group (17.5 ± 11.2 U/ml) (P = 0.004). It was not any significant difference between the levels of IgM and IgG antibodies in patients with MA or MO migraine headache. In addition, the mean HIT6 score was significantly more in patients with MA (65.5 ± 4.7) compared to those with MO (54.9 ± 5.3) migraine headache (P < 0.001). The only significant correlation was found between the IgG antibody level and the HIT6 score in patients with MA (r = 0.407; P = 0.011) and MO (r = 0.499; P = 0.002) migraine headache. There was significant relationship between the normal and high levels of IgG antibody and the severity of headache (P = 0.002) in all the patients. The risk of migraine occurrence in patients was not significantly associated with the levels of IgG and IgM antibodies.Conclusion: Further investigation should be designed to gain better conclusion about the role of H. Pylori treatment and eradication in the course of migraine headaches.

Keywords

References

  1. Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors. JAMA 1992; 267(1): 64-9.
  2. Diener HC, Kaube H, Limmroth V. A practical guide to the management and prevention of migraine. Drugs 1998; 56(5): 811-24.
  3. de Veries B, Frants RR, Ferrari MD, van den Maagdenberg AM. Molecular genetics of migraine. Hum Genet 2009; 126(1): 115-32.
  4. Deleu D, Hanssens Y, Worthing EA. Symptomatic and prophylactic treatment of migraine: a critical reappraisal. Clin Neuropharmacol 1998; 21(5): 267-79.
  5. Jahromi SR, Abolhasani M, Meysamie A, Togha M. The effect of body fat mass and fat free mass on migraine headache. Iran J Neurol 2013; 12(1): 23-7.
  6. Jones R, Lydeard S. Irritable bowel syndrome in the general population. BMJ 1992; 304(6819): 87-90.
  7. Holtmann G, Goebell H, Holtmann M, Talley NJ. Dyspepsia in healthy blood donors. Pattern of symptoms and association with Helicobacter pylori. Dig Dis Sci 1994; 39(5): 1090-8.
  8. Imanieh M, Dehghani SM, Haghighat M, Irani M, Yousefi M. Migraine headache and acid peptic diseases in children. Iran Red Crescent Med J 2009; 11(2): 181-3.
  9. Gasbarrini A, De Luca A, Fiore G, Franceschi F, Ojetti VV, Torre ES, et al. Primary headache and helicobacter pylori. Int J Angiol 1998; 7(4): 310-2.
  10. Gasbarrini A, Gabrielli M, Fiore G, Candelli M, Bartolozzi F, De Luca A, et al. Association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura. Cephalalgia 2000; 20(6): 561-5.
  11. Yiannopoulou KG, Efthymiou A, Karydakis K, Arhimandritis A, Bovaretos N, Tzivras M. Helicobacter pylori infection as an environmental risk factor for migraine without aura. J Headache Pain 2007; 8(6): 329-33.
  12. Hosseinzadeh M, Khosravi A, Saki K, Ranjbar R. Evaluation of Helicobacter pylori infection in patients with common migraine headache. Arch Med Sci 2011; 7(5): 844-9.
  13. Pacifico L, Anania C, Osborn JF, Ferraro F, Chiesa C. Consequences of Helicobacter pylori infection in children. World J Gastroenterol 2010; 16(41): 5181-94.
  14. Tunca A, Turkay C, Tekin O, Kargili A, Erbayrak M. Is Helicobacter pylori infection a risk factor for migraine? A case-control study. Acta Neurol Belg 2004; 104(4): 161-4.
  15. Bradbeer L, Thakkar S, Liu A, Nanan R. Childhood headache and H. pylori--a possible association. Aust Fam Physician 2013; 42(3): 134-6.
  16. Asghari N, Nassaji M, Shojaei H, Mosavi S, Ghorbani R. The effect of Helicobacter pylori eradication on migraine without aura. Iran J Neurol 2013; 12 (Suppl 1): 65.
  17. Faraji F, Zarinfar N, Zanjani AT, Morteza A. The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial. Pain Physician 2012; 15(6): 495-8.
  18. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988; 8(Suppl 7): 1-96.
  19. Bagley CL, Rendas-Baum R, Maglinte GA, Yang M, Varon SF, Lee J, et al. Validating Migraine-Specific Quality of Life Questionnaire v2.1 in episodic and chronic migraine. Headache 2012; 52(3): 409-21.
  20. Pinessi L, Savi L, Pellicano R, Rainero I, Valfre W, Gentile S, et al. Chronic Helicobacter pylori infection and migraine: a case-control study. Headache 2000; 40(10): 836-9.
  21. Caselli M, Chiamenti CM, Soriani S, Fanaro S. Migraine in children and Helicobacter pylori. Am J Gastroenterol 1999; 94(4): 1116-8.
  22. Malaty HM, Graham DY. Importance of childhood socioeconomic status on the current prevalence of Helicobacter pylori infection. Gut 1994; 35(6): 742-5.
  23. Bakhshipour A, Momeni M, Ramroodi N. Effect of Helicobacter pylori treatment on the number and severity of migraine attacks. Zahedan J Res Med Sci 2012; 14(6): 6-8. [In Persian].
  24. Gasbarrini A, De Luca A, Fiore G, Gambrielli M, Franceschi F, Ojetti V, et al. Beneficial effects of Helicobacter pylori eradication on migraine. Hepatogastroenterology 1998; 45(21): 765-70.
  25. Gervil M, Ulrich V, Kaprio J, Olesen J, Russell MB. The relative role of genetic and environmental factors in migraine without aura. Neurology 1999; 53(5): 995-9.
  26. Mavromichalis I, Zaramboukas T, Giala MM. Migraine of gastrointestinal origin. Eur J Pediatr 1995; 154(5): 406-10.
  27. Pradalier A, Devars du Mayne JF. Migraines and digestive disorders. Gastroenterol Clin Biol 2005; 29(2): 156-61. [In French].
  28. Ware JE, Jr., Bjorner JB, Kosinski M. Practical implications of item response theory and computerized adaptive testing: a brief summary of ongoing studies of widely used headache impact scales. Med Care 2000; 38(9 Suppl): II73-II82.
  29. Kosinski M, Bayliss MS, Bjorner JB, Ware JE, Garber WH, Batenhorst A, et al. A six-item short-form survey for measuring headache impact: the HIT-6. Qual Life Res 2003; 12(8): 963-74.
  30. Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997; 40(3): 297-301.
  31. Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 1991; 32(12): 1473-7.
  32. Crabtree JE. Role of cytokines in pathogenesis of Helicobacter pylori-induced mucosal damage. Dig Dis Sci 1998; 43(9 Suppl): 46S-55S.
  33. Hirschl AM. Helicobacter pylori: pathogens, pathomechanisms and epidemiology. Wien Klin Wochenschr 1994; 106(17): 538-42. [In German].
  34. Nagata K, Yu H, Nishikawa M, Kashiba M, Nakamura A, Sato EF, et al. Helicobacter pylori generates superoxide radicals and modulates nitric oxide metabolism. J Biol Chem 1998; 273(23): 14071-3.
  35. Ciancarelli I, Di MC, Tozzi-Ciancarelli MG, De Matteis G, Marini C, Carolei A. Helicobacter pylori infection and migraine. Cephalalgia 2002; 22(3): 222-5.
  36. Tunca A, Ardicoglu Y, Kargili A, Adam B. Migraine, Helicobacter pylori, and oxidative stress. Helicobacter 2007; 12(1): 59-62.
Journal of Isfahan Medical School
Volume 33, Issue 356 - Serial Number 356
September and October 2015
Pages 1796-1803

Files

History

  • Receive Date: 28 December 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics