Trace Blood Elements and Severity of Parkinson’s Disease

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Pharmacology, School of Medical Sciences, Islamic Azad University, Najafabad Branch AND Researcher, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Isfahan Neurosciences Research Center AND Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Isfahan Health Research Station, National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Parkinson's disease (PD) is a degenerative disorder of the nervous system and it seems that disturbances in trace elements homeostasis mediate progression of the disease. This study aimed to compare the levels of trace elements (Fe, Cu and Zn) in various stages of Parkinson's disease and to assess their correlation with the severity of the disease.Methods: Serum concentrations of trace elements were measured via Hitachi 902 biochemistry analysis in 109 patients with Parkinson's disease. Then, the severity of disease was evaluated and scored in four stages of 1-1.5, 2-2.5, 3, and 4-5 according to Hoehn and Yahr (HY) staging and also motor part of the Unified Parkinson’s Disease Rating Scale III (UPDRS III).Findings: All trace elements levels were within normal reference values and did not differ significantly between different Hoehn and Yahr stages (Fe: P = 0.670, Cu: P = 0.540, Zn: P = 0.340). Only patients with higher Hoehn and Yahr stages were older (P = 0.026). When the severity of Parkinson's disease was evaluated using UPDRS III, only there were significant association between age and the scale (P = 0.024).Conclusion: In this study, we confirmed only the age as a factor correlated with severity of Parkinson's disease. To clarify actual role of trace elements in this disease, more precise examination should be designed.

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 308 - Serial Number 308
September and October 2015
Pages 1870-1878

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History

  • Receive Date: 13 September 2014
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

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