The Effect of Ondansetron and Metoclopramide in Nausea and Vomiting of Pregnancy

Document Type : Original Article(s)

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

2 MSc Student, Student Research Committee, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Medical Student, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Bachelor of Midwifery, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: Nausea and vomiting of pregnancy (NVP) are seen in 50-90% of pregnancies. Mild to moderate NVP in the first trimester of pregnancy in most patients can be cured by ensuring them. However, in severe cases medical therapy to reduce nausea and vomiting is inevitable. Ondansetron as a drug effective in reducing nausea and vomiting is one of the therapies for the treatment of NVP that recently has been proposed. This study compared the effectiveness of Ondansetron and Metoclopramide in the treatment of NVP Methods: In a clinical trial study 70 pregnant women with NVP were selected in Sahid Beheshti hospital in 2010 and randomly divided in 2 groups. The first group administered oral administration of Metoclopramide and the second group were treated by Ondansetron for 3 weeks. The daily frequency of nausea and vomiting and medication side effects were studied before starting the intervention and three days, a week, two weeks and three weeks after treatment in the two groups. Data analysis was done by χ2, Fisher exact test and Student t–test. Finding: The results showed that there was not a significant difference between groups on the trend of change of nausea during treatment (P = 0.27) but the number of vomiting in Ondansetron group was significantly lower than other group (P = 0.04). Conclusion: Ondansetron have more favorable effect in controlling NVP. If the patient accept and this drug is safe in pregnancy, it can be used to control NVP during pregnancy. Keywords: Methoclopramide, Ondansetron, Nausea, Vomiting, Pregnancy.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 131 - Serial Number 131
January and February 2011
Pages 259-265

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History

  • Receive Date: 14 May 2011
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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